CRBN ligand-885

Cat. No.: HY-48024 Purity: 98.10%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

CRBN ligand-885 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-885 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-885 Chemical Structure

CAS No. : 2758531-21-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-885 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-885 can be linked to a target protein ligand via a linker to form a PROTAC.

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

205.21

Formula

C₁₁H₁₁NO₃

CAS No.

2758531-21-2

Appearance

Solid

Color

Purple to purplish red

SMILES

O=C1NC(=O)C(C2=CC=C(O)C=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (97.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8731 mL	24.3653 mL	48.7306 mL
5 mM	0.9746 mL	4.8731 mL	9.7461 mL
10 mM	0.4873 mL	2.4365 mL	4.8731 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.10%

Select Batch:

Data Sheet (243 KB) SDS (393 KB)

COA (248 KB) HNMR (266 KB) RP-HPLC (249 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8731 mL	24.3653 mL	48.7306 mL	121.8264 mL
	5 mM	0.9746 mL	4.8731 mL	9.7461 mL	24.3653 mL
	10 mM	0.4873 mL	2.4365 mL	4.8731 mL	12.1826 mL
	15 mM	0.3249 mL	1.6244 mL	3.2487 mL	8.1218 mL
	20 mM	0.2437 mL	1.2183 mL	2.4365 mL	6.0913 mL
	25 mM	0.1949 mL	0.9746 mL	1.9492 mL	4.8731 mL
	30 mM	0.1624 mL	0.8122 mL	1.6244 mL	4.0609 mL
	40 mM	0.1218 mL	0.6091 mL	1.2183 mL	3.0457 mL
	50 mM	0.0975 mL	0.4873 mL	0.9746 mL	2.4365 mL
	60 mM	0.0812 mL	0.4061 mL	0.8122 mL	2.0304 mL
	80 mM	0.0609 mL	0.3046 mL	0.6091 mL	1.5228 mL

CRBN ligand-885 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-8852758531-21-2CRBN ligand885CRBN ligand 885Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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CRBN ligand-885

CRBN ligand-885 Related Antibodies

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CRBN ligand-885 Related Antibodies

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