Daurisoline-d₁₁  (Synonyms: (R,R)-Daurisoline-d₁₁)

Daurisoline-d₁₁ is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer^[1][2].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

621.81

C₃₇H₃₁D₁₁N₂O₆

70553-76-3

OC1=C(C2=C(CCN([C@@H]2CC3=C(C([2H])=C(C(OC4=C(C([2H])=C(C([2H])=C4[2H])C[C@H]5N(CCC6=C5C([2H])=C(C(OC)=C6[2H])OC)C)[2H])=C3[2H])O)[2H])C)C([2H])=C1OC)[2H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu Q, et al. Effect of daurisoline on HERG channel electrophysiological function and protein expression. J Nat Prod. 2012 Sep 28;75(9):1539-45.  [Content Brief]

  [2]. Wu MY, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8(44):77673-77684.  [Content Brief]