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Art. -Nr.: HY-188123

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NAMPT ligand-1

NAMPT ligand-1 is a ligand targeting NAMPT, consisting of a NAMPT-binding domain, a linker, and a maleimide-fused enediyne warhead with a cyclopropane-modified alkyne terminus. NAMPT ligand-1 can be used to synthesize PROTEC NAMPT Degrader-1 (HY-189001). NAMPT ligand-1 induces the degradation of NAMPT via proximity-induced radical oxidation, and this process is independent of endogenous proteolytic mechanisms. NAMPT ligand-1 can be used in ovarian cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₀H₄₁NO₄
Molecular Weight:479.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NAMPT ligand-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

Chemical Information

Molecular Weight 479.65
Formel C₃₀H₄₁NO₄
SMILES

O=C(O)CCCCCN1C(C(C#CC(C2CC2)CCCC)=C(C#CC(C3CC3)CCCC)C1=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li X, et al. Enediyne Chimeras for Targeted NAMPT Degradation: Enhancing Cytotoxicity via a Radical Clock. The Journal of organic chemistry. 2026 Aug 07;91(31):10747-10752. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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