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Cat. No.: HY-189001

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PROTEC NAMPT Degrader-1

PROTEC NAMPT Degrader-1 is a NAMPT PROTEC degrader. PROTEC NAMPT Degrader-1 binds to NAMPT via non-covalent interactions and degrades this protein through a proximity-induced radical oxidation mechanism mediated by cyclopropane radical clock, independent of proteasomal or lysosomal pathways. PROTEC NAMPT Degrader-1 exhibits anticancer activity against ovarian cancer. It can be used in relevant studies on ovarian cancer (Pink: NAMPT ligand: (HY-188123); Linker: (HY-188124)).

For research use only. We do not sell to patients.

Formula: C₄₆H₆₄N₄O₄
Molecular Weight:737.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTEC NAMPT Degrader-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	CC₅₀	0.24 μM	Cytotoxicity against human ovarian cancer A2780 cells assessed as reduction in cell viability incubated for 24 h by CCK-8 method. Cytotoxicity against human ovarian cancer A2780 cells assessed as reduction in cell viability incubated for 24 h by CCK-8 method.	42504523

In Vitro

PROTEC NAMPT Degrader-1 (Compound PROTEC-4) binds stably to NAMPT with a highly favorable interaction network, supporting proximity-driven radical oxidative degradation of the target protein^[1].
PROTEC NAMPT Degrader-1 (24 h) potently reduces viability of ovarian cancer A2780 cells with a CC₅₀ of 0.24 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 737.02
Formula C₄₆H₆₄N₄O₄
SMILES

O=C(NCCCCCCCCNC(/C=C/C1=CC=CN=C1)=O)CCCCCN2C(C(C#CC(C3CC3)CCCC)=C(C#CC(C4CC4)CCCC)C2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li X, et al. Enediyne Chimeras for Targeted NAMPT Degradation: Enhancing Cytotoxicity via a Radical Clock. The Journal of organic chemistry. 2026 Aug 07;91(31):10747-10752. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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