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Cat. No.: HY-179105

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Axl-IN-20

Axl-IN-20 (Compound w11) is a selective, orally active AXL inhibitor, with an IC₅₀ of 5 nM. Axl-IN-20 has antitumor activity against hematological malignancies.

For research use only. We do not sell to patients.

CAS No.: 2487649-59-0
Formula: C₂₆H₂₃N₇O₂
Molecular Weight:465.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Axl-IN-20 Chemical Structure

CAS No.: 2487649-59-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Axl-IN-20 (Compound w11) is a selective, orally active AXL inhibitor, with an IC₅₀ of 5 nM. Axl-IN-20 has antitumor activity against hematological malignancies^[1].

IC₅₀ & Target

IC_50[1]

All TAM Receptor Isoforms :

Chemical Information

CAS No. 2487649-59-0
Molecular Weight 465.51
Formula C₂₆H₂₃N₇O₂
SMILES

CN1C=C(C2=C1N=CN=C2N)C3=CC=C(C=C3)NC(C4=C5CCCN5N(C4=O)C6=CC=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun M, et al. Structure-based drug discovery of novel penta- or hexa-bicyclo-pyrazolone derivatives as potent and selective AXL inhibitors. RSC Med Chem. 2025 Aug 9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Axl-IN-20

All TAM Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Axl-IN-20 Related Classifications

HY-179105 Related Classifications