Ppif - peptidylprolyl isomerase F (cyclophilin F) Gene

Also Known as CypD; CyP-D; CyP-F; PPIase

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105675

Summary

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including negative regulation of ATPase activity; positive regulation of release of cytochrome c from mitochondria; and regulation of proton transport. Acts upstream of or within apoptotic mitochondrial changes; necroptotic process; and response to oxidative stress. Located in mitochondrion. Part of mitochondrial permeability transition pore complex. Is expressed in lower jaw tooth and tooth. Orthologous to human PPIF (peptidylprolyl isomerase F). [provided by Alliance of Genome Resources, Apr 2022]

Ppif Products (1)

mRNA Protein Name
NM_134084.1 NP_598845.1 peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22726440 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic mitochondrial changes IGI
IGI: Inferred from genetic interaction
18350175 MGI
acts upstream of or within apoptotic process IGI
IGI: Inferred from genetic interaction
19293339 MGI
involved in cellular response to arsenic-containing substance IMP
IMP: Inferred from mutant phenotype
21281446 MGI
involved in cellular response to calcium ion IMP
IMP: Inferred from mutant phenotype
15800626 MGI
involved in cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
15800626 MGI
acts upstream of or within mitochondrial depolarization IGI
IGI: Inferred from genetic interaction
19293339 MGI
acts upstream of or within mitochondrion organization IGI
IGI: Inferred from genetic interaction
19293339 MGI
acts upstream of or within muscle structure development IGI
IGI: Inferred from genetic interaction
19293339 MGI
acts upstream of or within necroptotic process IGI
IGI: Inferred from genetic interaction
22726440 MGI
involved in negative regulation of ATP-dependent activity IMP
IMP: Inferred from mutant phenotype
21281446 MGI
involved in negative regulation of oxidative phosphorylation IMP
IMP: Inferred from mutant phenotype
21281446 MGI
involved in negative regulation of oxidative phosphorylation uncoupler activity IMP
IMP: Inferred from mutant phenotype
21281446 MGI
involved in programmed cell death IMP
IMP: Inferred from mutant phenotype
15800627 MGI
acts upstream of or within regulation of mitochondrial membrane permeability IGI
IGI: Inferred from genetic interaction
22726440 MGI
involved in regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
16103352 MGI
involved in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
15800626 MGI
involved in regulation of proton-transporting ATPase activity, rotational mechanism IMP
IMP: Inferred from mutant phenotype
19801635 MGI
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
15800626 MGI
acts upstream of or within response to oxidative stress IGI
IGI: Inferred from genetic interaction
22726440 MGI
acts upstream of or within skeletal muscle fiber differentiation IGI
IGI: Inferred from genetic interaction
19293339 MGI
Cellular Component GO Annotation Evidence References Source
part of mitochondrial permeability transition pore complex IMP
IMP: Inferred from mutant phenotype
31489369 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase F, mitochondrial

  • PPIase F

  • cyclophilin D

  • cyclophilin F

  • mitochondrial Cyclophilin D

  • peptidyl-prolyl cis-trans isomerase, mitochondrial

  • rotamase F

Ppif Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ppif Q99KR7 Tp53 Mus musculus P02340
Anti Bait CoIP
22726440
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10951 PPIF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179416 CypD-IN-6 Inhibitor / Unkown
HY-179417 CypD-IN-7 Inhibitor / Unkown
HY-RS18784 Ppif Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25273 Ppif Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppif NCBI NCBI:10105