Trp53 - transformation related protein 53 Gene

Also Known as bbl; bfy; bhy; p44; p53; Tp53

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22059

About Trp53

Chromosome 11: 69,471,185-69,482,699 forward strand.GRCm39:CM001004.3

This gene has 6 transcripts (splice variants), 251 orthologues, 2 paralogues and is associated with 250 phenotypes. Ubiquitous expression in thymus adult (RPKM 69.1), ovary adult (RPKM 56.5) and 28 other tissues.

Summary

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, Apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Trp53 Products (2)

mRNA Protein Name
NM_001127233.1 NP_001120705.1 cellular tumor antigen p53 isoform b
NM_011640.3 NP_035770.2 cellular tumor antigen p53 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21159655 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
16286009 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12135983 MGI
enables MDM2/MDM4 family protein binding IPI
IPI: Inferred from physical interaction
20818388 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10205143 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22897442 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15657445 MGI
enables histone deacetylase regulator activity IDA
IDA: Inferred from direct assay
15657445 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9194565 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
24240685 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell lineage commitment IMP
IMP: Inferred from mutant phenotype
8788039 MGI
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
14744935 MGI
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
11092819 MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator IDA
IDA: Inferred from direct assay
11790307 MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator IGI
IGI: Inferred from genetic interaction
16199867 MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IGI
IGI: Inferred from genetic interaction
16107883 MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
IDA: Inferred from direct assay
10710310 MGI
acts upstream of or within T cell differentiation in thymus IGI
IGI: Inferred from genetic interaction
16357222 MGI
acts upstream of or within T cell lineage commitment IMP
IMP: Inferred from mutant phenotype
8788039 MGI
acts upstream of or within T cell proliferation involved in immune response IGI
IGI: Inferred from genetic interaction
16357222 MGI
acts upstream of or within apoptotic process IDA
IDA: Inferred from direct assay
16183742 MGI
acts upstream of or within apoptotic process IGI
IGI: Inferred from genetic interaction
17325035 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
17912366 MGI
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
17434459 MGI
acts upstream of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within cardiac septum morphogenesis IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
10973261 MGI
involved in cellular response to UV IDA
IDA: Inferred from direct assay
23629966 MGI
acts upstream of or within cellular response to UV IGI
IGI: Inferred from genetic interaction
14963330 MGI
acts upstream of or within cellular response to UV-C IGI
IGI: Inferred from genetic interaction
24014029 MGI
acts upstream of or within cellular response to gamma radiation IDA
IDA: Inferred from direct assay
10710310 MGI
involved in cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
16213212 MGI
acts upstream of or within cellular response to ionizing radiation IGI
IGI: Inferred from genetic interaction
16286009 MGI
acts upstream of or within cellular response to stress IGI
IGI: Inferred from genetic interaction
26158450 MGI
acts upstream of or within central nervous system development IGI
IGI: Inferred from genetic interaction
16199867 MGI
acts upstream of or within cerebellum development IDA
IDA: Inferred from direct assay
24013501 MGI
acts upstream of or within chromosome organization IGI
IGI: Inferred from genetic interaction
17053789 MGI
involved in circadian behavior IMP
IMP: Inferred from mutant phenotype
24051492 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
24051492 MGI
involved in determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
20818388 MGI
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
17912366 MGI
acts upstream of or within embryo development ending in birth or egg hatching IGI
IGI: Inferred from genetic interaction
16702401 MGI
acts upstream of or within embryonic organ development IGI
IGI: Inferred from genetic interaction
17470788 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: Inferred from mutant phenotype
24051492 MGI
acts upstream of fibroblast proliferation IGI
IGI: Inferred from genetic interaction
16107883 MGI
acts upstream of or within fibroblast proliferation IGI
IGI: Inferred from genetic interaction
26334721 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
17332504 MGI
acts upstream of or within gastrulation IGI
IGI: Inferred from genetic interaction
17000767 MGI
acts upstream of glial cell proliferation IGI
IGI: Inferred from genetic interaction
10973261 MGI
acts upstream of glucose catabolic process to lactate via pyruvate IMP
IMP: Inferred from mutant phenotype
20935145 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
22821713 MGI
NOT acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
9425892 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
9288110 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IDA
IDA: Inferred from direct assay
12135983 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IGI
IGI: Inferred from genetic interaction
20434500 MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
IDA: Inferred from direct assay
16213212 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
IGI: Inferred from genetic interaction
15983387 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
12135983 MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
20818388 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
16407291 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to hypoxia IMP
IMP: Inferred from mutant phenotype
20935145 MGI
acts upstream of or within mitochondrial DNA repair IMP
IMP: Inferred from mutant phenotype
24101517 MGI
acts upstream of mitophagy IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within mitotic G1 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
16107883 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
17116431 MGI
acts upstream of or within necroptotic process IGI
IGI: Inferred from genetic interaction
22726440 MGI
acts upstream of or within negative regulation of DNA replication IDA
IDA: Inferred from direct assay
11884608 MGI
acts upstream of or within negative regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
11884608 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
24051492 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19749791 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
8183579 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
10591652 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19749791 MGI
acts upstream of or within negative regulation of fibroblast proliferation IGI
IGI: Inferred from genetic interaction
16107883 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
12952892 MGI
acts upstream of or within negative regulation of gene expression IGI
IGI: Inferred from genetic interaction
18625840 MGI
acts upstream of or within negative regulation of glial cell proliferation IGI
IGI: Inferred from genetic interaction
10973261 MGI
acts upstream of or within negative regulation of glucose catabolic process to lactate via pyruvate IMP
IMP: Inferred from mutant phenotype
20935145 MGI
acts upstream of or within negative regulation of miRNA processing IGI
IGI: Inferred from genetic interaction
21522133 MGI
acts upstream of or within negative regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within negative regulation of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
8612582 MGI
acts upstream of or within negative regulation of neuroblast proliferation IGI
IGI: Inferred from genetic interaction
9608530 MGI
acts upstream of or within negative regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
23277542 MGI
acts upstream of or within negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
10591653 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8183579 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15657445 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19749791 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15657445 MGI
acts upstream of neuroblast proliferation IGI
IGI: Inferred from genetic interaction
9608530 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10911993 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15485914 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9608530 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17591690 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15735665 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
15735665 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
9024662 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17068116 MGI
acts upstream of or within positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within positive regulation of cellular senescence IGI
IGI: Inferred from genetic interaction
17053789 MGI
involved in positive regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
10562313 MGI
acts upstream of or within positive regulation of mitochondrial membrane permeability IGI
IGI: Inferred from genetic interaction
22726440 MGI
acts upstream of or within positive regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
10894779 MGI
acts upstream of or within positive regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10911993 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9608530 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
19749791 MGI
involved in positive regulation of programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
27258785 MGI
acts upstream of or within positive regulation of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
17210642 MGI
involved in positive regulation of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
20818388 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7677753 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22362889 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20434500 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16407291 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
11799106 MGI
acts upstream of or within protein stabilization IGI
IGI: Inferred from genetic interaction
18625840 MGI
acts upstream of or within rRNA transcription IGI
IGI: Inferred from genetic interaction
18809582 MGI
acts upstream of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within regulation of DNA damage response, signal transduction by p53 class mediator IGI
IGI: Inferred from genetic interaction
21522133 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12135983 MGI
acts upstream of or within regulation of cell cycle IGI
IGI: Inferred from genetic interaction
18332125 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
15898111 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
10716720 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12878730 MGI
acts upstream of or within regulation of cellular senescence IGI
IGI: Inferred from genetic interaction
22904064 MGI
acts upstream of or within regulation of fibroblast apoptotic process IGI
IGI: Inferred from genetic interaction
17116431 MGI
acts upstream of or within regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17571083 MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in apoptotic process IGI
IGI: Inferred from genetic interaction
14963330 MGI
acts upstream of or within regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
17515607 MGI
acts upstream of or within regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15483136 MGI
acts upstream of or within regulation of thymocyte apoptotic process IGI
IGI: Inferred from genetic interaction
17210642 MGI
acts upstream of or within regulation of tissue remodeling IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24013501 MGI
acts upstream of or within release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
15483136 MGI
acts upstream of or within release of cytochrome c from mitochondria IGI
IGI: Inferred from genetic interaction
14963330 MGI
acts upstream of or within response to UV IDA
IDA: Inferred from direct assay
14744935 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
10815637 MGI
acts upstream of or within response to X-ray IDA
IDA: Inferred from direct assay
11884608 MGI
acts upstream of or within response to X-ray IMP
IMP: Inferred from mutant phenotype
22821713 MGI
acts upstream of or within response to gamma radiation IDA
IDA: Inferred from direct assay
14744935 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
17068116 MGI
acts upstream of or within response to ischemia IMP
IMP: Inferred from mutant phenotype
22044588 MGI
acts upstream of or within response to oxidative stress IGI
IGI: Inferred from genetic interaction
22726440 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
17591690 MGI
acts upstream of or within response to salt stress IGI
IGI: Inferred from genetic interaction
16571598 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
9098922 MGI
acts upstream of or within signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
26334721 MGI
acts upstream of or within somitogenesis IGI
IGI: Inferred from genetic interaction
17320900 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
10591653 MGI
acts upstream of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
17210642 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18212064 MGI
involved in type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
23629966 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11799106 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11799106 MGI
located in germ cell nucleus IDA
IDA: Inferred from direct assay
12524542 MGI
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
22726440 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12667443 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11799106 MGI
located in replication fork IDA
IDA: Inferred from direct assay
15364958 MGI
located in site of double-strand break IDA
IDA: Inferred from direct assay
24550317 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Trp53 Protein Structure

P53_TAD

P53_TAD: pfam08563 (8 - 30)

P53

P53: cd08367 (105 - 285)

P53_tetramer

P53_tetramer: pfam07710 (315 - 349)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

cellular tumor antigen p53

  • ME-delta123p53

  • mutant p53

  • p53 cellular tumor antigen

  • tumor suppressor p53

  • tumor supressor p53

Trp53 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tp53 P02340 Pten Mus musculus O08586
Anti Bait CoIP
23123091
Intra
Tp53 P02340 Sod2 Mus musculus P09671
Anti Bait CoIP
21909133
Intra
Tp53 P02340 Pin1 Mus musculus Q9QUR7
Anti Bait CoIP
21741598
Intra
Tp53 P02340 Bach1 Mus musculus P97302
Anti Bait CoIP
19011633
Cross
Tp53 P02340 BCL2L1 Homo sapiens Q07817-1
Anti Bait CoIP
16151013
Intra
Tp53 P02340 Trim24 Mus musculus Q64127
TAP
19556538
Intra
Tp53 P02340 Mdm2 Mus musculus P23804-1
Anti Bait CoIP
20697359
Intra
Tp53 P02340 Smarcd1 Mus musculus Q61466
Y2H
18303029
Intra
Tp53 P02340 Smarcd1 Mus musculus Q61466
Anti Tag CoIP
18303029
Intra
Tp53 P02340 Ep300 Mus musculus B2RWS6
Crosslink
25117711
Intra
Tp53 P02340 Ep300 Mus musculus B2RWS6
Anti Bait CoIP
9194565
Intra
Tp53 P02340 Rps27a Mus musculus P62991
Anti Bait CoIP
21857681
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
18448518
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
21122074
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
28536627
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
26960425
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
20621096
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
10329544
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
23980194
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
16480949
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
21670284
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
18025262
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Y2H
37025149
Cross
Tp53 P02340 lt_sv40 Simian virus 40 P03070
Anti Bait CoIP
10637512
Intra
Tp53 P02340 Mdm2 Mus musculus P23804
Anti Bait CoIP
21857681
Intra
Tp53 P02340 Mdm2 Mus musculus P23804
TAP
19556538
Intra
Tp53 P02340 Mdm2 Mus musculus P23804
Anti Bait CoIP
17936560
Intra
Tp53 P02340 Polg Mus musculus P54099
Anti Bait CoIP
21909133
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14912 TP53 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14913 Tp53 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15102 Trp53 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0391G L-Citrulline (GMP) Inhibitor / Unkown