Trim24 - tripartite motif-containing 24 Gene

Also Known as TIF1; Tif1a; TIF1alpha; TIF1-alpha; A130082H20Rik; D430004I05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21848

Summary

The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Trim24 Products (3)

mRNA Protein Name
NM_001272064.1 NP_001258993.1 transcription intermediary factor 1-alpha isoform 2
NM_001272076.1 NP_001259005.1 transcription intermediary factor 1-alpha isoform 3
NM_145076.4 NP_659542.3 transcription intermediary factor 1-alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
10318760 MGI
enables nuclear receptor binding IDA
IDA: Inferred from direct assay
15322135 MGI
enables p53 binding IPI
IPI: Inferred from physical interaction
19556538 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8978696 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
10562550 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18026104 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
19909775 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19556538 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19556538 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
18287084 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
18026104 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18026104 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10562550 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
18026104 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18026104 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
7744009 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
18026104 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18026104 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
10562550 MGI
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
19556538 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
10562550 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19556538 MGI
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
19556538 MGI
acts upstream of or within regulation of signal transduction by p53 class mediator IGI
IGI: Inferred from genetic interaction
19556538 MGI
acts upstream of or within regulation of vitamin D receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18287084 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11331580 MGI
located in euchromatin IDA
IDA: Inferred from direct assay
10318760 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
10525195 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
10318760 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10318760 MGI
located in perichromatin fibrils IDA
IDA: Inferred from direct assay
10318760 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription intermediary factor 1-alpha

  • E3 ubiquitin-protein ligase Trim24

  • RING-type E3 ubiquitin transferase TIF1-alpha

  • transcriptional intermediary factor 1, alpha

  • tripartite motif-containing protein 24

Trim24 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Trim24 Q64127 Trim33 Mus musculus Q99PP7
Anti Bait CoIP
21531907
Intra
Trim24 Q64127 Cbx5 Mus musculus Q61686
Pull Down
8978696
Intra
Trim24 Q64127 Tp53 Mus musculus P02340
Anti Bait CoIP
19556538
Intra
Trim24 Q64127 Cbx1 Mus musculus P83917
Pull Down
8978696
Intra
Trim24 Q64127 Cbx1 Mus musculus P83917
Y2H
8978696
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111519 dTRIM24 Inhibitor 99.89% Unkown
HY-102000B IACS-9571 hydrochloride Inhibitor 98.27% Unkown
HY-12518 OF-1 Inhibitor 98.93% Unkown
HY-143332 TRIM24/BRPF1-IN-2 Inhibitor 98.74% Unkown
HY-RS15029 TRIM24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-102000 IACS-9571 Inhibitor / Unkown
HY-102000A IACS-9571 TFA Inhibitor / Unkown
HY-161393 RB-CO-PEG5-C2-CO-VH032 / Unkown
HY-122626 BRPF1B/TRIM24-IN-1 Inhibitor / Unkown
HY-RS17565 Trim24 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24025 Trim24 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim24 NCBI NCBI:8805