TRIM24 - tripartite motif containing 24 Gene

Homo sapiens

Also known as PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA

Gene ID: 8805 | Gene type: protein coding

About TRIM24

Cytogenetic location: 7q33-q34 Genomic coordinates (GRCh38): 7:138,460,259-138,589,996 (from NCBI)

This gene has 6 transcripts (splice variants), 138 orthologues, 80 paralogues and is associated with 75 phenotypes. Ubiquitous expression in testis (RPKM 19.9), ovary (RPKM 16.3) and 25 other tissues.

Summary

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TRIM24 Products(2)

mRNA	Protein	Name
NM_003852.4	NP_003843.3	transcription intermediary factor 1-alpha isoform b
NM_015905.3	NP_056989.2	transcription intermediary factor 1-alpha isoform a

TRIM24 Protein Structure

zf-B_box

PHD

Bromodomain

0
200
400
600
800
1050 a.a.

Protein Preferred Names

Protein Names

transcription intermediary factor 1-alpha

E3 ubiquitin-protein ligase TRIM24

Recombinant TRIM24 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700503	TRIM24 Protein, Human (P. pastoris, His)	O15164 (K891-K1012)	≥95%

Related Diseases

Diseases

Alias

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Aortic Malignant Tumor

Aortic Malignant Neoplasm

Malignant Aortic Neoplasm

Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111519	dTRIM24	Inhibitor	99.92%	Unkown
HY-102000B	IACS-9571 hydrochloride	Inhibitor	99.85%	Unkown
HY-12518	OF-1	Inhibitor	98.28%	Unkown
HY-102000	IACS-9571	Inhibitor	/	Unkown
HY-143332	TRIM24/BRPF1-IN-2	Inhibitor	/	Unkown
HY-RS15029	TRIM24 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIM24	VGNC	VGNC:36321
Rattus norvegicus	TRIM24	RGD	RGD:1560596
Macaca mulatta	TRIM24	VGNC	VGNC:78562
Mus musculus	TRIM24	MGD	MGI:109275
Felis catus	TRIM24	VGNC	VGNC:80746
Canis familiaris	TRIM24	VGNC	VGNC:51835
Others	TRIM24	NCBI

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