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Cat. No.: HY-113249

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Aldosterone 18-glucuronide

Aldosterone 18-glucuronide is a urinary metabolite of Aldosterone (HY-113313). It exhibits 100% specificity in distinguishing primary aldosteronism from essential hypertension, but has relatively low overall sensitivity. There is no difference in sensitivity of Aldosterone 18-glucuronide between hypokalemic and normokalemic primary aldosteronism. Aldosterone 18-glucuronide can be used for the research of primary aldosteronism.

For research use only. We do not sell to patients.

CAS No.: 3604-86-2
Formula: C₂₇H₃₆O₁₁
Molecular Weight:536.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aldosterone 18-glucuronide Chemical Structure

CAS No.: 3604-86-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 3604-86-2
Molecular Weight 536.57
Formula C₂₇H₃₆O₁₁
SMILES

[H][C@@](C1)(O2)[C@@]([C@@]3(C(CC4)=CC(CC3)=O)C)([H])[C@]4([H])[C@@](CC[C@@H]5C(CO)=O)([H])[C@]15C2O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Schirpenbach C, et al. Confirmatory testing in normokalaemic primary aldosteronism: the value of the saline infusion test and urinary aldosterone metabolites. Eur J Endocrinol. 2006;154(6):865-873. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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