PSMD14 - proteasome 26S subunit, non-ATPase 14 Gene

Also Known as PAD1; POH1; RPN11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10213

About PSMD14

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,308,425-161,411,717 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 24.9), testis (RPKM 22.1) and 25 other tissues.

Summary

This gene encodes a component of the 26S Proteasome. The 26S Proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S Proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

PSMD14 Products (1)

mRNA	Protein	Name
NM_005805.6	NP_005796.1	26S proteasome non-ATPase regulatory subunit 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase activator activity	IMP IMP: Inferred from mutant phenotype	18162577	GOA
enables metal-dependent deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	22909820	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	18162577	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	22909820	GOA
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	22909820	GOA
involved in protein K63-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	22909820	GOA
involved in regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	18162577	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome regulatory particle, lid subcomplex	IMP IMP: Inferred from mutant phenotype	22909820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD14 Protein Structure

JAB

MitMem_reg

0
100
200
310 a.a.

Protein Preferred Names	Protein Names
26S proteasome non-ATPase regulatory subunit 14	26S proteasome regulatory subunit rpn11

PSMD14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMD14	O00487	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	PSMD14	O00487	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Y2H Prey Pooling	25416956
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Y2H Prey Pooling	32296183
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Y2H Array	25416956
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Y2H Array	32296183
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Validated Y2H	25416956
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Anti Tag CoIP	26496610
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Anti Tag CoIP	19615732
Intra	PSMD14	O00487	PSMD7	Homo sapiens	P51665	Validated Y2H	32296183
Intra	PSMD14	O00487	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PSMD14	O00487	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PSMD14	O00487	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PSMD14	O00487	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	PSMD14	O00487	DPY30	Homo sapiens	Q9C005	Y2H Array	25416956
Intra	PSMD14	O00487	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	PSMD14	O00487	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PSMD14 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82505	PSMD14 Antibody (YA2250)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172878	HDAC/PSMD14-IN-1		/	Unkown
HY-RS11322	PSMD14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18429	Psmd14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24910	Psmd14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PSMD14	MGD	MGI:1913284
Rattus norvegicus	PSMD14	RGD	RGD:1594532
Canis familiaris	PSMD14	VGNC	VGNC:45110
Felis catus	PSMD14	VGNC	VGNC:64415
Bos taurus	PSMD14	VGNC	VGNC:33465
Macaca mulatta	PSMD14	VGNC	VGNC:76269
Others	PSMD14	NCBI