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United States

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Cat. No.: HY-P992058

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Leukotuximab

(Synonyms: ART-140; DNP-001; EGX-040)

Leukotuximab (ART-140; EGX-040) is an anti-JL1 mAb and an anti-leukemic agent. Leukotuximab targets the JL1 epitope of CD43 and exerts cytotoxic effects on JL1-positive leukemia cells. Except for thymocytes and some bone marrow mononuclear cells, Leukotuximab causes no damage to most normal tissues. Leukotuximab can be used in the research of acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndrome.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Leukotuximab Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Species Reactivity
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Species Reactivity

Human

In Vivo

The JL1 antigen is expressed on leukemia cells in more than half of AML patients. The anti-JL1 antibody Leukotuximab has been used in a Phase I study for acute leukemia cases in Korea^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

6693 [NCBI]

Accession

P16150

Target

CD43/Leukosialin

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[Leukotuximab]
Synonyms

ART-140; DNP-001; EGX-040
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Rashidi A, et al. Antigen-specific immunotherapy for acute myeloid leukemia: where are we now, and where do we go from here?[J]. Expert review of hematology, 2016, 9(4): 335-350.

[2]. Park H S, et al. Expression of JL1 antigen in acute leukemia and myelodysplastic syndrome[J]. Blood, 2015, 126(23): 3826.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Species Reactivity
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

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Leukotuximab

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Leukotuximab Related Classifications

HY-P992058 Related Classifications