2. Metabolic Enzyme/Protease
  3. CETP
  4. DRL-17822

DRL-17822 is a selective cholesteryl ester transfer protein (CETP) inhibitor. DRL-17822 increases high-density lipoprotein levels. The exposure of DRL-17822 nanocrystal formulation increases significantly after a high-fat breakfast. The exposure of DRL-17822 in the fasted state is higher than that of its nanocrystal formulation. DRL-17822 can be used in the research of type II hyperlipidemia and atherosclerotic cardiovascular disease.

For research use only. We do not sell to patients.

DRL-17822

DRL-17822 Chemical Structure

CAS No. : 898911-09-6

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DRL-17822 Related Antibodies

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Description

DRL-17822 is a selective cholesteryl ester transfer protein (CETP) inhibitor. DRL-17822 increases high-density lipoprotein levels. The exposure of DRL-17822 nanocrystal formulation increases significantly after a high-fat breakfast. The exposure of DRL-17822 in the fasted state is higher than that of its nanocrystal formulation. DRL-17822 can be used in the research of type II hyperlipidemia and atherosclerotic cardiovascular disease[1].

In Vitro

DRL-17822 does not cross Caco-2 cell monolayers in measurable amounts, and may moderately inhibit recombinant human CYP3A4[1].
DRL-17822 is highly lipophilic, water-insoluble, and extensively bound to plasma proteins across species[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DRL-17822 Related Antibodies
In Vivo

DRL-17822 (10 mg/kg; i.v.; single dose) is hardly excreted in urine but shows moderate fecal excretion in male Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male)[1]
Dosage: 10 mg/kg
Administration: i.v.; single dose
Result: Recovered approximately 0.004% of the dose in urine within 24 hours.
Recovered approximately 12.5% of the dose in feces within 24 hours.
Molecular Weight

603.60

Formula

C30H31F6N7
CAS No.
SMILES

FC(F)(C1=CC(CN(CC2=CC3=C(N=C2N(CC4CC4)CC5CC5)C(C)=CC=C3)C6=NN(C)N=N6)=CC(C(F)(F)F)=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DRL-17822 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DRL-17822898911-09-6DRL17822DRL 17822CETPCholesteryl ester transfer proteinatherosclerotic cardiovascular diseaseCYP3A4male Wistar ratsCaco-2 cellmale beagle dogstype ii hyperlipidemiahigh-density lipoproteinCYP isoenzymesInhibitorinhibitorinhibit

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