dual FXR/PPARδ agonist-2
dual FXR/PPARδ agonist-2 is a FXR/PPARδ dual agonist through hybridation of FXR agonist GW-4064 and PPARδ agonist GW-0742.dual FXR/PPARδ agonist-2 displays potent dual-target activities with a FXR agonistic EC50 of 12.28 nM and 69 % PPARδ activation at 100 nM. dual FXR/PPARδ agonist-2 shows anti-fibrotic effects in pulmonary fibrosis mouse model.
For research use only. We do not sell to patients.
- Formula: C26H29N7O5
- Molecular Weight:519.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
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FXR 12.28 nM (EC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis mice models[1]
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Dosage:40 mg/kg
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Administration:Intraperitoneally injection, daily for 21 days
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Result:Reduced lesion density (fewer and smaller foci) and diminished septal thickening.
Suppressed collagen accumulation and fibrotic progression.
Attenuated α-SMA deposition.
Chemical Information
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Molecular Weight 519.55
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Formula C26H29N7O5
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SMILES
CC1=NOC(C2=CC=C(C=C2)CN(C)C)=C1COC(N3CCN(CC3)C4=NN5C(C(O)=O)=CN=C5C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
dual FXR/PPARδ agonist-2 Related Classifications
HY-175516 Related Classifications
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