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Cat. No.: HY-173435

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E3 ligase Ligand 60

E3 ligase Ligand 60 is a ligand for E3 ligase, used for the synthesis of JV8 (HY-173433).

For research use only. We do not sell to patients.

CAS No.: 2250014-82-3
Formula: C₂₃H₃₂N₄O₃S
Molecular Weight:444.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

E3 ligase Ligand 60 Chemical Structure

CAS No.: 2250014-82-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

E3 ligase Ligand 60 is a ligand for E3 ligase, used for the synthesis of JV8 (HY-173433)^[1].

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 2250014-82-3
Molecular Weight 444.59
Formula C₂₃H₃₂N₄O₃S
SMILES

N[C@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li T, et al. Non-invasive in vivo monitoring of PROTAC-mediated protein degradation using an environment-sensitive reporter. Nat Commun. 2025 Feb 22;16(1):1892. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
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E3 ligase Ligand 60

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E3 ligase Ligand 60 Related Classifications

HY-173435 Related Classifications