EGFR-IN-108 chloride
EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC50 value of 5.8 nM for hEGFR. EGFR-IN-108 chloride induces apoptosis and has anti-proliferative activity against cancer cells. EGFR-IN-108 chloride also has anti-angiogenic effects.
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- Fòrmula: C45H40Cl3F3N8O3Ru
- Peso molecular:1005.28
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Ru4S (0.2-100 μM; 48 h) shows cytotoxicity on HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T cells, with IC50 values of 23.76, 2.47, 6.24, 5.35, 29.90, 33.15 μM respectively[1].
Ru4S (0.78-50 μM; 48 h) induces apoptosis in HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T cells
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Concentration:0.2-100 μM
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Incubation Time:48 h
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Result:exhibited cytotoxicity.
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Cell Line:HepG2 cells
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Concentration:0.78, 3.12, 12.5, and 50 μM
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Incubation Time:48 h
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Result:increased Sub G1 (p < 0.0001) and decreased G0/G1, S, and G2/M percentages (p < 0.05) at 0.78 μM. And slightly increased Sub G1 (p < 0.01), slightly decreased G0/G1 (p < 0.01), and decreased G2/M (p < 0.05) at 3.12 and 12.5 μM. Increased Sub G1(p < 0.0001) and decreased S (p < 0.01), and did not affect the G0/G1 and G2/M phases at 50 μM.
Chemical Information
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Peso molecular 1005.28
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Fòrmula C45H40Cl3F3N8O3Ru
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SMILES
CC1=[N]2[Ru+2]3([N]4=C(C)C=CC=C4C5=CC=CC(C)=[N]35)([N]6=CC=C(OC7=CC=C(NC(NC8=CC=C(Cl)C(C(F)(F)F)=C8)=O)C=C7)C=C6C9=O)([NH]9C)[N]%10=C(C)C=CC=C%10C2=CC=C1.[Cl-].[Cl-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-108 chloride Related Classifications
HY-163402 Related Classifications
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