IL15RA - interleukin 15 receptor subunit alpha Gene

Also Known as CD215

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3601

About IL15RA

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,948,900-5,978,741 (from NCBI)

This gene has 22 transcripts (splice variants) and 89 orthologues. Ubiquitous expression in gall bladder (RPKM 5.8), lung (RPKM 5.5) and 24 other tissues.

Summary

This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of Other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of Apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

IL15RA Products (7)

mRNA	Protein	Name
NM_001243539.2	NP_001230468.1	interleukin-15 receptor subunit alpha isoform 3
NM_001256765.1	NP_001243694.1	interleukin-15 receptor subunit alpha isoform 4
NM_001351095.2	NP_001338024.1	interleukin-15 receptor subunit alpha isoform 5
NM_001351096.1	NP_001338025.1	interleukin-15 receptor subunit alpha isoform 6
NM_001351097.2	NP_001338026.1	interleukin-15 receptor subunit alpha isoform 7
NM_002189.4	NP_002180.1	interleukin-15 receptor subunit alpha isoform 1 precursor
NM_172200.3	NP_751950.2	interleukin-15 receptor subunit alpha isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-15 receptor activity	IDA IDA: Inferred from direct assay	15123770	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16284400	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15123770	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in interleukin-15-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15123770	GOA
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	15123770	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15123770	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-15 receptor subunit alpha	interleukin 15 receptor, alpha

IL15RA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL15RA	Q13261	IL15	Homo sapiens	P40933	GMS	23104097
Intra	IL15RA	Q13261	IL15	Homo sapiens	P40933	SPR	16284400
Intra	IL15RA	Q13261	IL15	Homo sapiens	P40933	X-Ray Diffraction	23104097

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL15RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70655	IL-15R alpha & IL-15 Protein, Human (HEK293, Fc)	Q13261-1 (I31-D96)&P40933-1 (N49-S162, N120D)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72592	IL-15R alpha Protein, Human (142a.a, HEK293, Fc)	Q13261-3 (I31-T172)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78154	IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi)	Q13261-1 (I31-T205)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77700	IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His)	Q13261-1 (I31-S108)&P40933-1 (N49-S162)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77699	IL-15R alpha & IL-15 Protein, Human (HEK293, His)	Q13261-1 (I31-S108)&P40933-1 (N49-S162)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78468	IL-15R alpha Protein, Human (HEK293, His-Avi)	Q13261-1 (I31-T205)	≥ 95%, as determined by Bis-Tris PAGE.

IL15RA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84532	CD215 Antibody (YA4229)	WB, ELISA	Human
HY-P84532A	CD215 Antibody (YA4229)(PBS only)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Ossification Of The Posterior Longitudinal Ligament Of Spine	OPLL Ossification Of The Posterior Longitudinal Ligament Of The Spine Ossification Of Posterior Longitudinal Ligament Of Spine Ossification, Posterior Longitudinal Ligament Spine
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99661	Inbakicept	Activator	99.06%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06693	IL15RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174635	Human IL15RA mRNA		/	Unkown
HY-RS19780	Il15ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26277	Il15ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991005	Larnefpendekin alfa	Inhibitor	97.16%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL15RA	RGD	RGD:1305149
Bos taurus	IL15RA	VGNC	VGNC:106779
Canis familiaris	IL15RA	VGNC	VGNC:41940
Mus musculus	IL15RA	MGD	MGI:104644
Macaca mulatta	IL15RA	VGNC	VGNC:73711
Felis catus	IL15RA	VGNC	VGNC:67761
Others	IL15RA	NCBI