CD215 Antibody (YA4229)(PBS only)
(Synonyms: IL15RA)CD215 Antibody (YA4229) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD215.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
CD215 Antibody (YA4229) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD215.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 28 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 28.2 kDa
Purified recombinant fragment of human CD215 (AA: extra 31-205) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD215 is a High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction; Does not bind IL15; Does not bind IL15; Does not bind IL15; Does not bind IL15[1][2][3].
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Subcellular Localization
Membrane; Single-pass type I membrane protein; Nucleus membrane; Single-pass type I membrane protein; Cell surface; Endoplasmic reticulum membrane; Single-pass type I membrane protein; Golgi apparatus membrane; Single-pass type I membrane protein; Cytoplasmic vesicle membrane; Single-pass type I membrane protein; Membrane; Single-pass type I membrane protein; Endoplasmic reticulum membrane; Single-pass type I membrane protein; Golgi apparatus membrane; Single-pass type I membrane protein; Cytoplasmic vesicle membrane; Single-pass type I membrane protein; Membrane; Single-pass type I membrane protein; Endoplasmic reticulum membrane; Single-pass type I membrane protein; Golgi apparatus membrane; Single-pass type I membrane protein; Cytoplasmic vesicle membrane; Single-pass type I membrane protein; Membrane; Single-pass type I membrane protein; Endoplasmic reticulum membrane; Single-pass type I membrane protein; Golgi apparatus membrane; Single-pass type I membrane protein; Cytoplasmic vesicle membrane; Single-pass type I membrane protein; Membrane; Single-pass type I membrane protein; Secreted, extracellular space
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Expression
Tissue_specificity:Expression in neutrophils (protein level) (PubMed:15123770) . Expression in the fetal brain, with higher expression in the hippocampus and cerebellum than in the cortex and thalamus (PubMed:12114302) . Soluble sIL-15RA levels are higher in all brain structures than in the membrane-bound type (PubMed:12114302) . Subtypes 1, 3, 4, 5, 6, 7, 8, and 9: widely expressed (PubMed:10480910, PubMed:8530383) . -
Subunit
The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (PubMed:17643103). Interacts with SYK (PubMed:15123770)
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SwissProt ID
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Synonyms
IL15RA
Documentation
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