IL15RA - interleukin 15 receptor subunit alpha Gene

Homo sapiens

Also known as CD215

Gene ID: 3601 | Gene type: protein coding

About IL15RA

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,948,900-5,978,741 (from NCBI)

This gene has 22 transcripts (splice variants) and 89 orthologues. Ubiquitous expression in gall bladder (RPKM 5.8), lung (RPKM 5.5) and 24 other tissues.

Summary

This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of Apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

IL15RA Products(7)

mRNA	Protein	Name
NM_001243539.2	NP_001230468.1	interleukin-15 receptor subunit alpha isoform 3
NM_001256765.1	NP_001243694.1	interleukin-15 receptor subunit alpha isoform 4
NM_001351095.2	NP_001338024.1	interleukin-15 receptor subunit alpha isoform 5
NM_001351096.1	NP_001338025.1	interleukin-15 receptor subunit alpha isoform 6
NM_001351097.2	NP_001338026.1	interleukin-15 receptor subunit alpha isoform 7
NM_002189.4	NP_002180.1	interleukin-15 receptor subunit alpha isoform 1 precursor
NM_172200.3	NP_751950.2	interleukin-15 receptor subunit alpha isoform 2 precursor

Protein Preferred Names

Protein Names

interleukin-15 receptor subunit alpha

interleukin 15 receptor, alpha

Recombinant IL15RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70655	IL-15R alpha & IL-15 Fusion Protein, Human (HEK293, Fc)	Q13261 (I31-D96)&P40933 (N49-S162, N120D)	≥95%
HY-P71971	IL15R alpha Protein, Human (HEK 293, hFc)	Q13261 (I31-T205)	≥95%
HY-P72592	IL-15R alpha Protein, Human (142a.a, HEK293, Fc)	Q13261-3 (I31-T172)	≥95%
HY-P78154	IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi)	Q13261 (I31-T205)	≥95%
HY-P77700	IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His)	Q13261 (I31-S108)&P40933 (N49-S162)	≥95%
HY-P77699	IL-15R alpha & IL-15 Protein, Human (HEK293, His)	Q13261 (I31-S108)&P40933 (N49-S162)	≥95%
HY-P78468	IL-15R alpha Protein, Human (HEK293, His-Avi)	Q13261 (I31-T205)	≥95%

Related Diseases

Diseases

Alias

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Ossification Of The Posterior Longitudinal Ligament Of Spine

OPLL	Ossification Of The Posterior Longitudinal Ligament Of The Spine
Ossification Of Posterior Longitudinal Ligament Of Spine	Ossification, Posterior Longitudinal Ligament Spine

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99661	Inbakicept	Activator	98.95%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06693	IL15RA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL15RA	RGD	RGD:1305149
Bos taurus	IL15RA	VGNC	VGNC:106779
Canis familiaris	IL15RA	VGNC	VGNC:41940
Mus musculus	IL15RA	MGD	MGI:104644
Macaca mulatta	IL15RA	VGNC	VGNC:73711
Felis catus	IL15RA	VGNC	VGNC:67761
Others	IL15RA	NCBI

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