WMK-1
WMK-1 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer, with significantly higher cytotoxicity against cancer cells than non-cancerous cells. WMK-1 triggers ferroptosis in cancer cells and cancer stem cells. WMK-1 can be used for the research of cancer.
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- No. CAS: 2814563-83-0
- Fòrmula: C35H51IN2O6
- Peso molecular:722.69
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
WMK-1 (compound 48) (48 h) potently inhibits viability of MDA-MB-231, Hela, T47D, Jurkat, HCT116, and HL-60 cancer cells with IC50 values ranging from 1.0 μM to 6.3 μM[1].
WMK-1 (48 h) potently inhibits viability of HeyA8 ovarian cancer cells (IC50 = 2.3 μM) and HeyA8sp ovarian cancer stem cell spheres (IC50 = 1.2 μM)[1].
WMK-1 (24 h) induces ferroptosis in HeyA8 ovarian cancer cells, HeyA8 ovarian cancer stem cells, and HeyA8 ovarian cancer stem cell spheres[1].
WMK-1 (5 μM; 6 h) increases lipid reactive oxygen species levels in MDA-MB-231 triple negative breast cancer cells[1].
WMK-1 (5 μM) induced cell death in MDA-MB-231 triple-negative breast cancer cells at indicated concentrations within 24 h, and this effect was significantly reversed by 30 μM liproxstatin-1 (HY-12726) pretreatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice (female)[1]
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Dosage:5 mg/kg; 10 mg/kg
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Administration:i.p.
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Result:Reduced ovarian cancer xenograft tumor size.
Caused no abnormal behavior or weight loss in treated animals during the entire study period.
Chemical Information
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No. CAS 2814563-83-0
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Peso molecular 722.69
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Fòrmula C35H51IN2O6
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SMILES
CC(C)(C)C1CCC2(OOC3(CCC(OC(NCCC[N+](CC4=CC=CC=C4)(C)CC5=CC=CC=C5)=O)CC3)OO2)CC1.[I-]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WMK-1 Related Classifications
HY-186145 Related Classifications
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