Etravirine-d8
Etravirine-d8 is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1142096-06-7
- Formel: C20H9D6BrN6O
- Molecular Weight:443.33
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-10570S
Nevirapine-d4Deuterium Labeled Nevirapine -
HY-137522
Zidovudine O-β-D-glucuronide sodiumZidovudine Metabolite -
HY-122482
β-RubromycinHIV Reverse Transcriptase Inhibitor -
HY-14588S
(rel)-Lopinavir-d8Stable Isotope -
HY-121096
FunalenoneMraY/MurG Inhibitor -
HY-10493S
Cobicistat-d8CYP3A Inhibitor -
HY-10353S
Raltegravir-d4Stable Isotope
Biologische Aktivität
Beschreibung
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS. Nr. 1142096-06-7
-
Unlabeled CAS 269055-15-4
-
Molecular Weight 443.33
-
Formel C20H9D6BrN6O
-
SMILES
O(C1=NC(NC2=CC=C(C#N)C=C2)=NC(N)=C1Br)C3=C(C([2H])([2H])[2H])C=C(C#N)C=C3C([2H])([2H])[2H]
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468 [Content Brief]
[3]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Etravirine-d8 Related Classifications
HY-132508S Related Classifications
Powered by Bioz