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Cat. No.: HY-10493S

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Cobicistat-d₈

(Synonyms: GS-9350-d₈)

Cobicistat-d8 (GS-9350-d8) is a deuterated version of Cobicistat (HY-10493). Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) with IC₅₀ values of 30-285 nM. Cobicistat is a pharmacokinetic enhancer that enhances the absorption of anti-HIV active molecules.

For research use only. We do not sell to patients.

CAS No.: 2699607-48-0
Formula: C₄₀H₄₅D₈N₇O₅S₂
Molecular Weight:784.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Cobicistat-d₈ Chemical Structure

CAS No.: 2699607-48-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Cytochrome P450 Isoforms :

All HIV Isoforms :

In Vitro

Stable heavy isotopes of hydrogen，carbon，and other elements have been incorporated into drug molecules，largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2699607-48-0
Unlabeled Cas 1004316-88-4
Molecular Weight 784.07
Formula C₄₀H₄₅D₈N₇O₅S₂
SMILES

CN(CC1=CSC(C(C)C)=N1)C(N[C@H](C(N[C@H](CC[C@H](CC2=CC=CC=C2)NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4)=O)CCN5C([2H])(C([2H])(OC([2H])(C5([2H])[2H])[2H])[2H])[2H])=O
Synonyms

GS-9350-d₈
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Temesgen Z. Cobicistat, a pharmacoenhancer for HIV treatments. Drugs Today (Barc). 2013 Apr;49(4):233-7. [Content Brief]

[3]. Lianhong Xu, et al. Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer. ACS Med. Chem. Lett., 2010, 1 (5), pp 209–213

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References

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Cobicistat-d8

All Cytochrome P450 Isoforms

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cobicistat-d8 Related Classifications

HY-10493S Related Classifications

Cobicistat-d₈

Cobicistat-d₈ Related Classifications