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Cat. No.: HY-N21921

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Euphoscopin A

Name: Euphoscopin A
Brand: MedChemExpress
SKU: HY-N21921
Availability: PreOrder

(Synonyms: 2-epi-Euphornin I)

Euphoscopin A (2-epi-Euphornin I) is a toxic lathyrane diterpene with Kv1.3 potassium channel inhibitory activity, can be found in fresh leaves and roots of Euphorbia helioscopia and aerial parts of Euphorbia fischeriana.

For research use only. We do not sell to patients.

CAS No.: 81542-94-1
Formula: C₃₁H₄₀O₈
Molecular Weight:540.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Euphoscopin A Chemical Structure

CAS No.: 81542-94-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

IC₅₀ & Target^[2]

Kv1.3

In Vitro

Euphoscopin A (compound 1) yields a p-bromobenzoate derivative after derivatization with p-bromobenzoyl chloride in pyridine^[1].
Euphoscopin A undergoes acetylation at 70°C to form Euphoscopin B (HY-N12730); it undergoes benzoylation at room temperature to form Euphoscopin C; and it can be oxidized by manganese dioxide at 70-80°C to form Euphoscopin D^[1].
Euphoscopin A (compound 13) (10-30 μM) inhibits the Kv1.3 ion channel in HEK-293 cells stably expressing Kv1.3, and also inhibits the hERG ion channel in HEK-293 cells stably expressing hERG^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 81542-94-1
Molecular Weight 540.64
Formula C₃₁H₄₀O₈
SMILES

C[C@@H]1/C=C\C(C)(C)C(C[C@@H](O)/C(C)=C/[C@]([C@@H](OC(C2=CC=CC=C2)=O)[C@H](C)C3)([H])[C@@]3(OC(C)=O)[C@@H]1OC(C)=O)=O
Synonyms

2-epi-Euphornin I
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yamamura S, et al. Diterpenes from Euphorbia helioscopia. Phytochemistry, 1989, 28(12): 3421‑3436.

[2]. Cai Q, et al. Diterpenoids from Euphorbia fischeriana with Kv1.3 Inhibitory Activity. Journal of Natural Products, 2023, 86(10): 2379‑2390.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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