Flupropanate (Synonyms: 2,2,3,3-Tetrafluoropropionic acid; 3H-Tetrafluoropropionic acid)

Cat. No.: HY-121139: Data Sheet Handling Instructions
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Flupropanate (2,2,3,3-Tetrafluoropropionic acid; 3H-Tetrafluoropropionic acid) is a soil-active selective herbicide and plant growth inhibitor that acts by inhibiting radicle growth and lipid biosynthesis in sensitive plants. Flupropanate exhibits high-efficiency control of Stipa weeds (such as Nassella neesiana and N. trichotoma) in pastures, and reduces the coverage of the invasive species Eragrostis curvula. Meanwhile, Flupropanate is sensitive to gramineous plants like ryegrass, but shows good selective tolerance to plantain, chicory and some leguminous plants. Studies show that in the protected area with Mediterranean climate in southwestern Australia, Flupropanate produces no significant non-target effects on native plant communities, functional groups or the endangered species Grevillea curviloba, indicating high ecological safety.

For research use only. We do not sell to patients.

Flupropanate Chemical Structure

CAS No. : 756-09-2

Size	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Liquid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Description

In Vitro

Flupropanate (0.3-2200 g ai/ha; 12-15 days) reduces radicle growth of tested pasture and weed species in a dose-dependent manner, with ryegrass cultivars and Nassella spp. being highly susceptible, and broadleaf species including plantain, strawberry clover, chicory 'Chico', and lucerne being relatively tolerant^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

146.04

Formula

C₃H₂F₄O₂

CAS No.

756-09-2

Appearance

Liquid

SMILES

O=C(O)C(F)(F)C(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1369.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.8474 mL	34.2372 mL	68.4744 mL
5 mM	1.3695 mL	6.8474 mL	13.6949 mL
10 mM	0.6847 mL	3.4237 mL	6.8474 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (34.24 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (34.24 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (34.24 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lamoureaux S L, et al. Flupropanate in vitro pasture species susceptibilities[J]. New Zealand Plant Protection, 2015, 68: 105-111.

[2]. Gosper C R, et al. Control of African lovegrass by flupropanate in a flora conservation context[J]. Australian Journal of Botany, 2025, 73(5): BT25005.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.8474 mL	34.2372 mL	68.4744 mL	171.1860 mL
	5 mM	1.3695 mL	6.8474 mL	13.6949 mL	34.2372 mL
	10 mM	0.6847 mL	3.4237 mL	6.8474 mL	17.1186 mL
	15 mM	0.4565 mL	2.2825 mL	4.5650 mL	11.4124 mL
	20 mM	0.3424 mL	1.7119 mL	3.4237 mL	8.5593 mL
	25 mM	0.2739 mL	1.3695 mL	2.7390 mL	6.8474 mL
	30 mM	0.2282 mL	1.1412 mL	2.2825 mL	5.7062 mL
	40 mM	0.1712 mL	0.8559 mL	1.7119 mL	4.2796 mL
	50 mM	0.1369 mL	0.6847 mL	1.3695 mL	3.4237 mL
	60 mM	0.1141 mL	0.5706 mL	1.1412 mL	2.8531 mL
	80 mM	0.0856 mL	0.4280 mL	0.8559 mL	2.1398 mL
	100 mM	0.0685 mL	0.3424 mL	0.6847 mL	1.7119 mL

Flupropanate Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flupropanate756-09-22,2,3,3-Tetrafluoropropionic acid 3H-Tetrafluoropropionic acidHerbicideEragrostis curvulachicoryradicle growthNassella neesianaGrevillea curvilobastipoid grassesryegrasslipid biosynthesisplantainN. trichotomaInhibitorinhibitorinhibit

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Flupropanate (Synonyms: 2,2,3,3-Tetrafluoropropionic acid; 3H-Tetrafluoropropionic acid)

Flupropanate Related Antibodies

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Biological Activity

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References

Customer Review

Flupropanate Related Antibodies

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