4-Fluorophenoxyacetic acid

Name: 4-Fluorophenoxyacetic acid
Brand: MedChemExpress
SKU: HY-W052234
Rating: 4.5 (1 reviews)

Cat. No.: HY-W052234 Purity: 99.07%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Fluorophenoxyacetic acid (4FPA) induces parthenocarpy. 4-Fluorophenoxyacetic acid (4FPA) protects cereals from piercing-sucking insects and thereby increases rice yield in the field.

For research use only. We do not sell to patients.

4-Fluorophenoxyacetic acid Chemical Structure

CAS No. : 405-79-8

Size	Price	Stock	Quantity
1 g	USD 30	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

4-Fluorophenoxyacetic acid (4FPA) induces parthenocarpy. 4-Fluorophenoxyacetic acid (4FPA) protects cereals from piercing-sucking insects and thereby increases rice yield in the field^[1]^[2].

Molecular Weight

170.14

Formula

C₈H₇FO₃

CAS No.

405-79-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=C(F)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (146.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8775 mL	29.3876 mL	58.7751 mL
5 mM	1.1755 mL	5.8775 mL	11.7550 mL
10 mM	0.5878 mL	2.9388 mL	5.8775 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.69 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.69 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (14.69 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.07%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (244 KB) HNMR (121 KB) RP-HPLC (95 KB)

Handling Instructions (2659 KB)

References

[1]. Burton R. Anderson. et al. Control of Annual Bluegrass and Crabgrass in Turf with Fluorophenoxyacetic Acids. Weed Science. January 1958 , pp. 52-58.

[2]. Wanwan Wang, et al. Induction of Defense in Cereals by 4-fluorophenoxyacetic Acid Suppresses Insect Pest Populations and Increases Crop Yields in the Field. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12017-12028. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.8775 mL	29.3876 mL	58.7751 mL	146.9378 mL
	5 mM	1.1755 mL	5.8775 mL	11.7550 mL	29.3876 mL
	10 mM	0.5878 mL	2.9388 mL	5.8775 mL	14.6938 mL
	15 mM	0.3918 mL	1.9592 mL	3.9183 mL	9.7959 mL
	20 mM	0.2939 mL	1.4694 mL	2.9388 mL	7.3469 mL
	25 mM	0.2351 mL	1.1755 mL	2.3510 mL	5.8775 mL
	30 mM	0.1959 mL	0.9796 mL	1.9592 mL	4.8979 mL
	40 mM	0.1469 mL	0.7347 mL	1.4694 mL	3.6734 mL
	50 mM	0.1176 mL	0.5878 mL	1.1755 mL	2.9388 mL
	60 mM	0.0980 mL	0.4898 mL	0.9796 mL	2.4490 mL
	80 mM	0.0735 mL	0.3673 mL	0.7347 mL	1.8367 mL
	100 mM	0.0588 mL	0.2939 mL	0.5878 mL	1.4694 mL