UBE2K - ubiquitin conjugating enzyme E2 K Gene

Also Known as LIG; HIP2; HYPG; UBC1; E2-25K

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3093

About UBE2K

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,698,136-39,782,792 (from NCBI)

This gene has 7 transcripts (splice variants), 282 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 24.1), thyroid (RPKM 17.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate Huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of Apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

UBE2K Products (6)

mRNA Protein Name
NM_001111112.2 NP_001104582.1 ubiquitin-conjugating enzyme E2 K isoform 2
NM_001111113.2 NP_001104583.1 ubiquitin-conjugating enzyme E2 K isoform 3
NM_001312646.2 NP_001299575.1 ubiquitin-conjugating enzyme E2 K isoform 4
NM_001312647.2 NP_001299576.1 ubiquitin-conjugating enzyme E2 K isoform 5 precursor
NM_001312648.2 NP_001299577.1 ubiquitin-conjugating enzyme E2 K isoform 5 precursor
NM_005339.5 NP_005330.1 ubiquitin-conjugating enzyme E2 K isoform 1
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
17500595 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16714285 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20061386 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: Inferred from direct assay
17873885 GOA
Biological Process GO Annotation Evidence Références Source
involved in cellular response to interferon-beta IMP
IMP: Inferred from mutant phenotype
24882218 GOA
involved in free ubiquitin chain polymerization IDA
IDA: Inferred from direct assay
24882218 GOA
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
24882218 GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
26707646 GOA
involved in positive regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24882218 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2K Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 147)

UBA

UBA: UBA/TS-N domain (162 - 197)

  • 0
  • 100
  • 200 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 K

  • E2 ubiquitin-conjugating enzyme K

UBE2K Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
UBE2K P61086 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
UBE2K P61086 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
UBE2K P61086 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
UBE2K P61086 TSN Homo sapiens Q15631 32296183
Intra
UBE2K P61086 TSN Homo sapiens Q15631 32296183
Intra
UBE2K P61086 TSN Homo sapiens Q15631 32296183
Intra
UBE2K P61086 RNF167 Homo sapiens Q9H6Y7 32814053
Intra
UBE2K P61086 RNF167 Homo sapiens Q9H6Y7 32814053
Intra
UBE2K P61086 RNF167 Homo sapiens Q9H6Y7 32814053
Intra
UBE2K P61086 ZFTRAF1 Homo sapiens P0DTL6 33961781
Intra
UBE2K P61086 ZFTRAF1 Homo sapiens P0DTL6 28514442
Intra
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9-2 32296183
Intra
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9-2 32296183
Intra
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9-2 32296183
Intra
UBE2K P61086 FAM163A Homo sapiens Q96GL9 32814053
Intra
UBE2K P61086 FAM163A Homo sapiens Q96GL9 32814053
Intra
UBE2K P61086 FAM163A Homo sapiens Q96GL9 32814053
Intra
UBE2K P61086 TRIM5 Homo sapiens Q9C035-3 32296183
Intra
UBE2K P61086 TRIM5 Homo sapiens Q9C035-3 32296183
Intra
UBE2K P61086 TRIM5 Homo sapiens Q9C035-3 32296183
Intra
UBE2K P61086 CAMK2A Homo sapiens Q9UQM7 32814053
Intra
UBE2K P61086 CAMK2A Homo sapiens Q9UQM7 32814053
Intra
UBE2K P61086 CAMK2A Homo sapiens Q9UQM7 32814053
Intra
UBE2K P61086 KRIT1 Homo sapiens O00522 32296183
Intra
UBE2K P61086 KRIT1 Homo sapiens O00522 32296183
Intra
UBE2K P61086 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
UBE2K P61086 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
UBE2K P61086 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
UBE2K P61086 TRIM35 Homo sapiens Q9UPQ4-2 32296183
Intra
UBE2K P61086 TRIM35 Homo sapiens Q9UPQ4-2 32296183
Intra
UBE2K P61086 TRIM35 Homo sapiens Q9UPQ4-2 32296183
Intra
UBE2K P61086 ADAL Homo sapiens Q6DHV7-2 32814053
Intra
UBE2K P61086 ADAL Homo sapiens Q6DHV7-2 32814053
Intra
UBE2K P61086 ADAL Homo sapiens Q6DHV7-2 32814053
Intra
UBE2K P61086 GLIPR1L2 Homo sapiens Q4G1C9-2 32814053
Intra
UBE2K P61086 GLIPR1L2 Homo sapiens Q4G1C9-2 32814053
Intra
UBE2K P61086 GLIPR1L2 Homo sapiens Q4G1C9-2 32814053
Intra
UBE2K P61086 RNF182 Homo sapiens Q8N6D2 32296183
Intra
UBE2K P61086 RNF182 Homo sapiens Q8N6D2 32296183
Intra
UBE2K P61086 RNF182 Homo sapiens Q8N6D2 32296183
Intra
UBE2K P61086 BFAR Homo sapiens Q9NZS9 32296183
Intra
UBE2K P61086 BFAR Homo sapiens Q9NZS9 32296183
Intra
UBE2K P61086 BFAR Homo sapiens Q9NZS9 32296183
Intra
UBE2K P61086 RNF166 Homo sapiens Q96A37 32296183
Intra
UBE2K P61086 RNF166 Homo sapiens Q96A37 32296183
Intra
UBE2K P61086 RNF166 Homo sapiens Q96A37 32296183
Intra
UBE2K P61086 SPSB2 Homo sapiens Q99619 32814053
Intra
UBE2K P61086 SPSB2 Homo sapiens Q99619 32814053
Intra
UBE2K P61086 SPSB2 Homo sapiens Q99619 32814053
Intra
UBE2K P61086 RNF185 Homo sapiens Q96GF1 32296183
Intra
UBE2K P61086 RNF185 Homo sapiens Q96GF1 32296183
Intra
UBE2K P61086 RNF185 Homo sapiens Q96GF1 32296183
Intra
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 25416956
Intra
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 32296183
Intra
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 32296183
Intra
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 32296183
Intra
UBE2K P61086 DTX3 Homo sapiens Q8N9I9 25416956
Intra
UBE2K P61086 MID1 Homo sapiens O15344 32296183
Intra
UBE2K P61086 MID1 Homo sapiens O15344 32296183
Intra
UBE2K P61086 MARCHF3 Homo sapiens Q86UD3 32814053
Intra
UBE2K P61086 MARCHF3 Homo sapiens Q86UD3 32814053
Intra
UBE2K P61086 MARCHF3 Homo sapiens Q86UD3 32814053
Intra
UBE2K P61086 MIPOL1 Homo sapiens Q8TD10 32296183
Intra
UBE2K P61086 MIPOL1 Homo sapiens Q8TD10 25416956
Intra
UBE2K P61086 MIPOL1 Homo sapiens Q8TD10 32296183
Intra
UBE2K P61086 MIPOL1 Homo sapiens Q8TD10 32296183
Intra
UBE2K P61086 SPSB1 Homo sapiens Q96BD6 32814053
Intra
UBE2K P61086 SPSB1 Homo sapiens Q96BD6 32814053
Intra
UBE2K P61086 SPSB1 Homo sapiens Q96BD6 32814053
Intra
UBE2K P61086 REL Homo sapiens Q04864 25416956
Intra
UBE2K P61086 REL Homo sapiens Q04864 25416956
Intra
UBE2K P61086 RNF5 Homo sapiens Q99942 32296183
Intra
UBE2K P61086 RNF5 Homo sapiens Q99942 25416956
Intra
UBE2K P61086 RNF5 Homo sapiens Q99942 32296183
Intra
UBE2K P61086 RNF5 Homo sapiens Q99942 32296183
Intra
UBE2K P61086 GNB2 Homo sapiens P62879 32814053
Intra
UBE2K P61086 GNB2 Homo sapiens P62879 32814053
Intra
UBE2K P61086 GNB2 Homo sapiens P62879 32814053
Intra
UBE2K P61086 EXOSC7 Homo sapiens Q15024 32296183
Intra
UBE2K P61086 EXOSC7 Homo sapiens Q15024 32296183
Intra
UBE2K P61086 EXOSC7 Homo sapiens Q15024 32296183
Intra
UBE2K P61086 DXO Homo sapiens O77932 32814053
Intra
UBE2K P61086 DXO Homo sapiens O77932 32814053
Intra
UBE2K P61086 DXO Homo sapiens O77932 32814053
Intra
UBE2K P61086 VPS11 Homo sapiens Q9H270 32814053
Intra
UBE2K P61086 VPS11 Homo sapiens Q9H270 32814053
Intra
UBE2K P61086 VPS11 Homo sapiens Q9H270 32814053
Intra
UBE2K P61086 CCNC Homo sapiens P24863 32296183
Intra
UBE2K P61086 CCNC Homo sapiens P24863 32296183
Intra
UBE2K P61086 TP53BP1 Homo sapiens Q12888 32814053
Intra
UBE2K P61086 TP53BP1 Homo sapiens Q12888 32814053
Intra
UBE2K P61086 TP53BP1 Homo sapiens Q12888 32814053
Intra
UBE2K P61086 HTT Homo sapiens P42858
Y2H
17500595
Intra
UBE2K P61086 CCNB1 Homo sapiens P14635 20965177
Intra
UBE2K P61086 DDIT4 Homo sapiens Q9NX09 32814053
Intra
UBE2K P61086 DDIT4 Homo sapiens Q9NX09 32814053
Intra
UBE2K P61086 DDIT4 Homo sapiens Q9NX09 32814053
Intra
UBE2K P61086 LAMTOR1 Homo sapiens Q6IAA8 32814053
Intra
UBE2K P61086 LAMTOR1 Homo sapiens Q6IAA8 32814053
Intra
UBE2K P61086 LAMTOR1 Homo sapiens Q6IAA8 32814053
Intra
UBE2K P61086 NEDD8 Homo sapiens Q15843 32814053
Intra
UBE2K P61086 NEDD8 Homo sapiens Q15843 32814053
Intra
UBE2K P61086 NEDD8 Homo sapiens Q15843 32814053
Intra
UBE2K P61086 TRIM27 Homo sapiens P14373 32296183
Intra
UBE2K P61086 TRIM27 Homo sapiens P14373 32296183
Intra
UBE2K P61086 TRIM27 Homo sapiens P14373 27107012
Intra
UBE2K P61086 TRIM27 Homo sapiens P14373 27107012
Intra
UBE2K P61086 TRIM27 Homo sapiens P14373
Y2H
27107012
Intra
UBE2K P61086 WFS1 Homo sapiens O76024 32814053
Intra
UBE2K P61086 WFS1 Homo sapiens O76024 32814053
Intra
UBE2K P61086 WFS1 Homo sapiens O76024 32814053
Intra
UBE2K P61086 SDCBP Homo sapiens O00560 32296183
Intra
UBE2K P61086 SDCBP Homo sapiens O00560 32296183
Intra
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9 25416956
Intra
UBE2K P61086 TRIM39 Homo sapiens Q9HCM9 25416956
Intra
UBE2K P61086 RNF183 Homo sapiens Q96D59 32296183
Intra
UBE2K P61086 RNF183 Homo sapiens Q96D59 32296183
Intra
UBE2K P61086 RNF183 Homo sapiens Q96D59 32296183
Intra
UBE2K P61086 CIAO2B Homo sapiens Q9Y3D0 32814053
Intra
UBE2K P61086 CIAO2B Homo sapiens Q9Y3D0 32814053
Intra
UBE2K P61086 CIAO2B Homo sapiens Q9Y3D0 32814053
Intra
UBE2K P61086 SIAH1 Homo sapiens Q8IUQ4 25416956
Intra
UBE2K P61086 SIAH1 Homo sapiens Q8IUQ4 25416956
Intra
UBE2K P61086 PAX6 Homo sapiens P26367 32296183
Intra
UBE2K P61086 PAX6 Homo sapiens P26367 32296183
Intra
UBE2K P61086 TRIM31 Homo sapiens Q9BZY9 32296183
Intra
UBE2K P61086 TRIM31 Homo sapiens Q9BZY9 32296183
Intra
UBE2K P61086 TRIM31 Homo sapiens Q9BZY9 32296183
Intra
UBE2K P61086 DDI1 Homo sapiens Q8WTU0 25416956
Intra
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 32296183
Intra
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 25416956
Intra
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 32296183
Intra
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 33961781
Intra
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 25416956
Intra
UBE2K P61086 RNF138 Homo sapiens Q8WVD3
TAP
27173435
Intra
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 32296183
Intra
UBE2K P61086 RNF138 Homo sapiens Q8WVD3 25416956
Intra
UBE2K P61086 RING1 Homo sapiens Q06587 32814053
Intra
UBE2K P61086 RING1 Homo sapiens Q06587 32814053
Intra
UBE2K P61086 RING1 Homo sapiens Q06587 32296183
Intra
UBE2K P61086 RING1 Homo sapiens Q06587 32296183
Intra
UBE2K P61086 RING1 Homo sapiens Q06587 32814053
Intra
UBE2K P61086 RING1 Homo sapiens Q06587 32296183
Intra
UBE2K P61086 PICK1 Homo sapiens Q9NRD5 32296183
Intra
UBE2K P61086 PICK1 Homo sapiens Q9NRD5 32296183
Intra
UBE2K P61086 PICK1 Homo sapiens Q9NRD5 32296183
Intra
UBE2K P61086 MARCHF7 Homo sapiens Q9H992 32296183
Intra
UBE2K P61086 MARCHF7 Homo sapiens Q9H992 32296183
Intra
UBE2K P61086 MARCHF7 Homo sapiens Q9H992 32296183
Intra
UBE2K P61086 TCAP Homo sapiens O15273 32814053
Intra
UBE2K P61086 TCAP Homo sapiens O15273 32814053
Intra
UBE2K P61086 TCAP Homo sapiens O15273 32814053
Intra
UBE2K P61086 TRIM50 Homo sapiens Q86XT4 32296183
Intra
UBE2K P61086 TRIM50 Homo sapiens Q86XT4 32296183
Intra
UBE2K P61086 TRIM50 Homo sapiens Q86XT4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2K Proteins

Cat. No. Nom du produit Accession Pureté
HY-P71405 UBE2K Protein, Human (GST) P61086-1 (M1-N200) ≥ 95%, as determined by reducing SDS-PAGE.

UBE2K Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P86900 HIP2/LIG Antibody (YA6593) WB, ICC/IF, IHC-P, FC Human, Mouse, Rat, Monkey

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language
  • Chromosome 5q14.3 Deletion Syndrome

  • 5q14.3 Microdeletion Syndrome

  • Mental Retardation, Autosomal Dominant 20

  • NEDHSIL

  • Autosomal Dominant Mental Retardation 20

  • Mrd20

  • Del(5)(Q14.3)

  • Monosomy 5q14.3

  • Intellectual Disability, Autosomal Dominant 20

  • Mental Retardation, Autosomal Dominant 20, Formerly

  • Mrd20, Formerly

  • Mental Retardation, Stereotypic Movements, Epilepsy, And/Or Cerebral Malformations

  • 5q14.3 Deletion Syndrome

  • Autosomal Dominant Intellectual Disability 20

  • Mental Retardation, Autosomal Dominant, Type 20

Liddle Syndrome 1
  • Liddle Syndrome

  • Pseudoaldosteronism

  • Liddle'S Syndrome

  • LIDLS1

  • Lidls

  • Pseudohyperaldosteronism

  • Pseudoprimary Hyperaldosteronism

  • Pseudohyperaldosteronism Type 1

  • Liddles Syndrome

Uterine Adnexa Cancer
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1
  • Hypophosphatemic Nephrolithiasis/Osteoporosis 1

  • NPHLOP1

  • Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1

  • Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1

Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Cortical Dysplasia, Complex, With Other Brain Malformations 6
  • Complex Cortical Dysplasia With Other Brain Malformations 6

  • CDCBM6

  • Cdcbm56

  • Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Huntington Disease
  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBE2K RGD RGD:1311626
Bos taurus UBE2K VGNC VGNC:36587
Macaca mulatta UBE2K VGNC VGNC:79957
Mus musculus UBE2K MGD MGI:1858216
Felis catus UBE2K VGNC VGNC:80098
Canis familiaris UBE2K VGNC VGNC:48057
Others UBE2K NCBI