UBE2K - ubiquitin conjugating enzyme E2 K Gene
Also Known as LIG; HIP2; HYPG; UBC1; E2-25K
Species: Homo sapiens
About UBE2K
This gene has 7 transcripts (splice variants), 282 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 24.1), thyroid (RPKM 17.9) and 25 other tissues.
Summary
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate Huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of Apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UBE2K Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001111112.2 | NP_001104582.1 | ubiquitin-conjugating enzyme E2 K isoform 2 |
| NM_001111113.2 | NP_001104583.1 | ubiquitin-conjugating enzyme E2 K isoform 3 |
| NM_001312646.2 | NP_001299575.1 | ubiquitin-conjugating enzyme E2 K isoform 4 |
| NM_001312647.2 | NP_001299576.1 | ubiquitin-conjugating enzyme E2 K isoform 5 precursor |
| NM_001312648.2 | NP_001299577.1 | ubiquitin-conjugating enzyme E2 K isoform 5 precursor |
| NM_005339.5 | NP_005330.1 | ubiquitin-conjugating enzyme E2 K isoform 1 |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17500595 | GOA |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
16714285 | GOA |
| enables ubiquitin-protein transferase activity |
IDA
IDA: Inferred from direct assay
|
20061386 | GOA |
| enables ubiquitin-ubiquitin ligase activity |
IDA
IDA: Inferred from direct assay
|
17873885 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in cellular response to interferon-beta |
IMP
IMP: Inferred from mutant phenotype
|
24882218 | GOA |
| involved in free ubiquitin chain polymerization |
IDA
IDA: Inferred from direct assay
|
24882218 | GOA |
| involved in positive regulation of peptidyl-threonine phosphorylation |
IDA
IDA: Inferred from direct assay
|
24882218 | GOA |
| involved in positive regulation of tumor necrosis factor-mediated signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
26707646 | GOA |
| involved in positive regulation of type I interferon-mediated signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
24882218 | GOA |
| involved in protein K48-linked ubiquitination |
IDA
IDA: Inferred from direct assay
|
20061386 | GOA |
UBE2K Protein Structure
UQ_con: Ubiquitin-conjugating enzyme (8 - 147)
UBA: UBA/TS-N domain (162 - 197)
- 0
- 100
- 200 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ubiquitin-conjugating enzyme E2 K |
|
UBE2K Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
UBE2K | P61086 | MID2 | Homo sapiens | Q9UJV3-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MID2 | Homo sapiens | Q9UJV3-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MID2 | Homo sapiens | Q9UJV3-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TSN | Homo sapiens | Q15631 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TSN | Homo sapiens | Q15631 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TSN | Homo sapiens | Q15631 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF167 | Homo sapiens | Q9H6Y7 | 32814053 | |
|
Intra
|
UBE2K | P61086 | RNF167 | Homo sapiens | Q9H6Y7 | 32814053 | |
|
Intra
|
UBE2K | P61086 | RNF167 | Homo sapiens | Q9H6Y7 | 32814053 | |
|
Intra
|
UBE2K | P61086 | ZFTRAF1 | Homo sapiens | P0DTL6 | 33961781 | |
|
Intra
|
UBE2K | P61086 | ZFTRAF1 | Homo sapiens | P0DTL6 | 28514442 | |
|
Intra
|
UBE2K | P61086 | TRIM39 | Homo sapiens | Q9HCM9-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM39 | Homo sapiens | Q9HCM9-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM39 | Homo sapiens | Q9HCM9-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | FAM163A | Homo sapiens | Q96GL9 | 32814053 | |
|
Intra
|
UBE2K | P61086 | FAM163A | Homo sapiens | Q96GL9 | 32814053 | |
|
Intra
|
UBE2K | P61086 | FAM163A | Homo sapiens | Q96GL9 | 32814053 | |
|
Intra
|
UBE2K | P61086 | TRIM5 | Homo sapiens | Q9C035-3 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM5 | Homo sapiens | Q9C035-3 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM5 | Homo sapiens | Q9C035-3 | 32296183 | |
|
Intra
|
UBE2K | P61086 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
UBE2K | P61086 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
UBE2K | P61086 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
UBE2K | P61086 | KRIT1 | Homo sapiens | O00522 | 32296183 | |
|
Intra
|
UBE2K | P61086 | KRIT1 | Homo sapiens | O00522 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM35 | Homo sapiens | Q9UPQ4-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM35 | Homo sapiens | Q9UPQ4-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM35 | Homo sapiens | Q9UPQ4-2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | ADAL | Homo sapiens | Q6DHV7-2 | 32814053 | |
|
Intra
|
UBE2K | P61086 | ADAL | Homo sapiens | Q6DHV7-2 | 32814053 | |
|
Intra
|
UBE2K | P61086 | ADAL | Homo sapiens | Q6DHV7-2 | 32814053 | |
|
Intra
|
UBE2K | P61086 | GLIPR1L2 | Homo sapiens | Q4G1C9-2 | 32814053 | |
|
Intra
|
UBE2K | P61086 | GLIPR1L2 | Homo sapiens | Q4G1C9-2 | 32814053 | |
|
Intra
|
UBE2K | P61086 | GLIPR1L2 | Homo sapiens | Q4G1C9-2 | 32814053 | |
|
Intra
|
UBE2K | P61086 | RNF182 | Homo sapiens | Q8N6D2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF182 | Homo sapiens | Q8N6D2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF182 | Homo sapiens | Q8N6D2 | 32296183 | |
|
Intra
|
UBE2K | P61086 | BFAR | Homo sapiens | Q9NZS9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | BFAR | Homo sapiens | Q9NZS9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | BFAR | Homo sapiens | Q9NZS9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF166 | Homo sapiens | Q96A37 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF166 | Homo sapiens | Q96A37 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF166 | Homo sapiens | Q96A37 | 32296183 | |
|
Intra
|
UBE2K | P61086 | SPSB2 | Homo sapiens | Q99619 | 32814053 | |
|
Intra
|
UBE2K | P61086 | SPSB2 | Homo sapiens | Q99619 | 32814053 | |
|
Intra
|
UBE2K | P61086 | SPSB2 | Homo sapiens | Q99619 | 32814053 | |
|
Intra
|
UBE2K | P61086 | RNF185 | Homo sapiens | Q96GF1 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF185 | Homo sapiens | Q96GF1 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF185 | Homo sapiens | Q96GF1 | 32296183 | |
|
Intra
|
UBE2K | P61086 | DTX3 | Homo sapiens | Q8N9I9 | 25416956 | |
|
Intra
|
UBE2K | P61086 | DTX3 | Homo sapiens | Q8N9I9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | DTX3 | Homo sapiens | Q8N9I9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | DTX3 | Homo sapiens | Q8N9I9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | DTX3 | Homo sapiens | Q8N9I9 | 25416956 | |
|
Intra
|
UBE2K | P61086 | MID1 | Homo sapiens | O15344 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MID1 | Homo sapiens | O15344 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MARCHF3 | Homo sapiens | Q86UD3 | 32814053 | |
|
Intra
|
UBE2K | P61086 | MARCHF3 | Homo sapiens | Q86UD3 | 32814053 | |
|
Intra
|
UBE2K | P61086 | MARCHF3 | Homo sapiens | Q86UD3 | 32814053 | |
|
Intra
|
UBE2K | P61086 | MIPOL1 | Homo sapiens | Q8TD10 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MIPOL1 | Homo sapiens | Q8TD10 | 25416956 | |
|
Intra
|
UBE2K | P61086 | MIPOL1 | Homo sapiens | Q8TD10 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MIPOL1 | Homo sapiens | Q8TD10 | 32296183 | |
|
Intra
|
UBE2K | P61086 | SPSB1 | Homo sapiens | Q96BD6 | 32814053 | |
|
Intra
|
UBE2K | P61086 | SPSB1 | Homo sapiens | Q96BD6 | 32814053 | |
|
Intra
|
UBE2K | P61086 | SPSB1 | Homo sapiens | Q96BD6 | 32814053 | |
|
Intra
|
UBE2K | P61086 | REL | Homo sapiens | Q04864 | 25416956 | |
|
Intra
|
UBE2K | P61086 | REL | Homo sapiens | Q04864 | 25416956 | |
|
Intra
|
UBE2K | P61086 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF5 | Homo sapiens | Q99942 | 25416956 | |
|
Intra
|
UBE2K | P61086 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF5 | Homo sapiens | Q99942 | 32296183 | |
|
Intra
|
UBE2K | P61086 | GNB2 | Homo sapiens | P62879 | 32814053 | |
|
Intra
|
UBE2K | P61086 | GNB2 | Homo sapiens | P62879 | 32814053 | |
|
Intra
|
UBE2K | P61086 | GNB2 | Homo sapiens | P62879 | 32814053 | |
|
Intra
|
UBE2K | P61086 | EXOSC7 | Homo sapiens | Q15024 | 32296183 | |
|
Intra
|
UBE2K | P61086 | EXOSC7 | Homo sapiens | Q15024 | 32296183 | |
|
Intra
|
UBE2K | P61086 | EXOSC7 | Homo sapiens | Q15024 | 32296183 | |
|
Intra
|
UBE2K | P61086 | DXO | Homo sapiens | O77932 | 32814053 | |
|
Intra
|
UBE2K | P61086 | DXO | Homo sapiens | O77932 | 32814053 | |
|
Intra
|
UBE2K | P61086 | DXO | Homo sapiens | O77932 | 32814053 | |
|
Intra
|
UBE2K | P61086 | VPS11 | Homo sapiens | Q9H270 | 32814053 | |
|
Intra
|
UBE2K | P61086 | VPS11 | Homo sapiens | Q9H270 | 32814053 | |
|
Intra
|
UBE2K | P61086 | VPS11 | Homo sapiens | Q9H270 | 32814053 | |
|
Intra
|
UBE2K | P61086 | CCNC | Homo sapiens | P24863 | 32296183 | |
|
Intra
|
UBE2K | P61086 | CCNC | Homo sapiens | P24863 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TP53BP1 | Homo sapiens | Q12888 | 32814053 | |
|
Intra
|
UBE2K | P61086 | TP53BP1 | Homo sapiens | Q12888 | 32814053 | |
|
Intra
|
UBE2K | P61086 | TP53BP1 | Homo sapiens | Q12888 | 32814053 | |
|
Intra
|
UBE2K | P61086 | HTT | Homo sapiens | P42858 | 17500595 | |
|
Intra
|
UBE2K | P61086 | CCNB1 | Homo sapiens | P14635 | 20965177 | |
|
Intra
|
UBE2K | P61086 | DDIT4 | Homo sapiens | Q9NX09 | 32814053 | |
|
Intra
|
UBE2K | P61086 | DDIT4 | Homo sapiens | Q9NX09 | 32814053 | |
|
Intra
|
UBE2K | P61086 | DDIT4 | Homo sapiens | Q9NX09 | 32814053 | |
|
Intra
|
UBE2K | P61086 | LAMTOR1 | Homo sapiens | Q6IAA8 | 32814053 | |
|
Intra
|
UBE2K | P61086 | LAMTOR1 | Homo sapiens | Q6IAA8 | 32814053 | |
|
Intra
|
UBE2K | P61086 | LAMTOR1 | Homo sapiens | Q6IAA8 | 32814053 | |
|
Intra
|
UBE2K | P61086 | NEDD8 | Homo sapiens | Q15843 | 32814053 | |
|
Intra
|
UBE2K | P61086 | NEDD8 | Homo sapiens | Q15843 | 32814053 | |
|
Intra
|
UBE2K | P61086 | NEDD8 | Homo sapiens | Q15843 | 32814053 | |
|
Intra
|
UBE2K | P61086 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM27 | Homo sapiens | P14373 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM27 | Homo sapiens | P14373 | 27107012 | |
|
Intra
|
UBE2K | P61086 | TRIM27 | Homo sapiens | P14373 | 27107012 | |
|
Intra
|
UBE2K | P61086 | TRIM27 | Homo sapiens | P14373 | 27107012 | |
|
Intra
|
UBE2K | P61086 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
UBE2K | P61086 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
UBE2K | P61086 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
UBE2K | P61086 | SDCBP | Homo sapiens | O00560 | 32296183 | |
|
Intra
|
UBE2K | P61086 | SDCBP | Homo sapiens | O00560 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM39 | Homo sapiens | Q9HCM9 | 25416956 | |
|
Intra
|
UBE2K | P61086 | TRIM39 | Homo sapiens | Q9HCM9 | 25416956 | |
|
Intra
|
UBE2K | P61086 | RNF183 | Homo sapiens | Q96D59 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF183 | Homo sapiens | Q96D59 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF183 | Homo sapiens | Q96D59 | 32296183 | |
|
Intra
|
UBE2K | P61086 | CIAO2B | Homo sapiens | Q9Y3D0 | 32814053 | |
|
Intra
|
UBE2K | P61086 | CIAO2B | Homo sapiens | Q9Y3D0 | 32814053 | |
|
Intra
|
UBE2K | P61086 | CIAO2B | Homo sapiens | Q9Y3D0 | 32814053 | |
|
Intra
|
UBE2K | P61086 | SIAH1 | Homo sapiens | Q8IUQ4 | 25416956 | |
|
Intra
|
UBE2K | P61086 | SIAH1 | Homo sapiens | Q8IUQ4 | 25416956 | |
|
Intra
|
UBE2K | P61086 | PAX6 | Homo sapiens | P26367 | 32296183 | |
|
Intra
|
UBE2K | P61086 | PAX6 | Homo sapiens | P26367 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM31 | Homo sapiens | Q9BZY9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM31 | Homo sapiens | Q9BZY9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM31 | Homo sapiens | Q9BZY9 | 32296183 | |
|
Intra
|
UBE2K | P61086 | DDI1 | Homo sapiens | Q8WTU0 | 25416956 | |
|
Intra
|
UBE2K | P61086 | RNF138 | Homo sapiens | Q8WVD3 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF138 | Homo sapiens | Q8WVD3 | 25416956 | |
|
Intra
|
UBE2K | P61086 | RNF138 | Homo sapiens | Q8WVD3 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF138 | Homo sapiens | Q8WVD3 | 33961781 | |
|
Intra
|
UBE2K | P61086 | RNF138 | Homo sapiens | Q8WVD3 | 25416956 | |
|
Intra
|
UBE2K | P61086 | RNF138 | Homo sapiens | Q8WVD3 | 27173435 | |
|
Intra
|
UBE2K | P61086 | RNF138 | Homo sapiens | Q8WVD3 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RNF138 | Homo sapiens | Q8WVD3 | 25416956 | |
|
Intra
|
UBE2K | P61086 | RING1 | Homo sapiens | Q06587 | 32814053 | |
|
Intra
|
UBE2K | P61086 | RING1 | Homo sapiens | Q06587 | 32814053 | |
|
Intra
|
UBE2K | P61086 | RING1 | Homo sapiens | Q06587 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RING1 | Homo sapiens | Q06587 | 32296183 | |
|
Intra
|
UBE2K | P61086 | RING1 | Homo sapiens | Q06587 | 32814053 | |
|
Intra
|
UBE2K | P61086 | RING1 | Homo sapiens | Q06587 | 32296183 | |
|
Intra
|
UBE2K | P61086 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
UBE2K | P61086 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
UBE2K | P61086 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MARCHF7 | Homo sapiens | Q9H992 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MARCHF7 | Homo sapiens | Q9H992 | 32296183 | |
|
Intra
|
UBE2K | P61086 | MARCHF7 | Homo sapiens | Q9H992 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TCAP | Homo sapiens | O15273 | 32814053 | |
|
Intra
|
UBE2K | P61086 | TCAP | Homo sapiens | O15273 | 32814053 | |
|
Intra
|
UBE2K | P61086 | TCAP | Homo sapiens | O15273 | 32814053 | |
|
Intra
|
UBE2K | P61086 | TRIM50 | Homo sapiens | Q86XT4 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM50 | Homo sapiens | Q86XT4 | 32296183 | |
|
Intra
|
UBE2K | P61086 | TRIM50 | Homo sapiens | Q86XT4 | 32296183 |
Recombinant UBE2K Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P71405 | UBE2K Protein, Human (GST) | P61086-1 (M1-N200) | ≥ 95%, as determined by reducing SDS-PAGE. |
UBE2K Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P86900 | HIP2/LIG Antibody (YA6593) | WB, ICC/IF, IHC-P, FC | Human, Mouse, Rat, Monkey |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language |
|
|
| Liddle Syndrome 1 |
|
|
| Uterine Adnexa Cancer |
|
|
| Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1 |
|
|
| Lung Cancer |
|
|
| Cortical Dysplasia, Complex, With Other Brain Malformations 6 |
|
|
| Huntington Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | UBE2K | RGD | RGD:1311626 |
| Bos taurus | UBE2K | VGNC | VGNC:36587 |
| Macaca mulatta | UBE2K | VGNC | VGNC:79957 |
| Mus musculus | UBE2K | MGD | MGI:1858216 |
| Felis catus | UBE2K | VGNC | VGNC:80098 |
| Canis familiaris | UBE2K | VGNC | VGNC:48057 |
| Others | UBE2K | NCBI |