RNF138 - ring finger protein 138 Gene

Also Known as NARF; HSD-4; STRIN; hNARF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51444

About RNF138

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:32,091,874-32,131,561 (from NCBI)

This gene has 9 transcripts (splice variants), 162 orthologues and 4 paralogues. Broad expression in testis (RPKM 31.9), bone marrow (RPKM 30.7) and 23 other tissues.

Summary

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RNF138 Products (3)

mRNA Protein Name
NM_001191324.2 NP_001178253.2 E3 ubiquitin-protein ligase RNF138 isoform 1
NM_016271.5 NP_057355.2 E3 ubiquitin-protein ligase RNF138 isoform 1
NM_198128.3 NP_937761.1 E3 ubiquitin-protein ligase RNF138 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19549727 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16714285 GOA
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
26502055 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
26502055 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA double-strand break processing involved in repair via single-strand annealing IMP
IMP: Inferred from mutant phenotype
26502057 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
26502055 GOA
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
26502055 GOA
Cellular Component GO Annotation Evidence References Source
located in site of double-strand break IDA
IDA: Inferred from direct assay
26502055 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF138 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (18 - 57)

zf-Di19

zf-Di19: Drought induced 19 protein (Di19), zinc-binding (156 - 216)

  • 0
  • 100
  • 200
  • 245 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF138

  • NLK-associated RING finger protein

RNF138 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF138 Q8WVD3 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
RNF138 Q8WVD3 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
RNF138 Q8WVD3 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
RNF138 Q8WVD3 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
RNF138 Q8WVD3 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
RNF138 Q8WVD3 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
RNF138 Q8WVD3 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
RNF138 Q8WVD3 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
RNF138 Q8WVD3 UBE2K Homo sapiens P61086
Y2H
19549727
Intra
RNF138 Q8WVD3 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
RNF138 Q8WVD3 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra
RNF138 Q8WVD3 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
RNF138 Q8WVD3 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
RNF138 Q8WVD3 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
RNF138 Q8WVD3 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12050 RNF138 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RNF138 RGD RGD:621485
Mus musculus RNF138 MGD MGI:1929211
Felis catus RNF138 VGNC VGNC:80479
Canis familiaris RNF138 VGNC VGNC:45631
Macaca mulatta RNF138 VGNC VGNC:76755
Bos taurus RNF138 VGNC VGNC:34022
Others RNF138 NCBI