MARCHF7 - membrane associated ring-CH-type finger 7 Gene

Also Known as AXO; AXOT; MARCH7; RNF177; MARCH-VII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64844

Summary

MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]
Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 28.8) and 25 other tissues.

MARCHF7 Products (26)

mRNA Protein Name
NM_001282805.2 NP_001269734.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001282806.2 NP_001269735.1 E3 ubiquitin-protein ligase MARCHF7 isoform b
NM_001282807.2 NP_001269736.1 E3 ubiquitin-protein ligase MARCHF7 isoform c
NM_001376234.1 NP_001363163.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376235.1 NP_001363164.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376236.1 NP_001363165.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376237.1 NP_001363166.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376238.1 NP_001363167.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376239.1 NP_001363168.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376240.1 NP_001363169.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376241.1 NP_001363170.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376242.1 NP_001363171.1 E3 ubiquitin-protein ligase MARCHF7 isoform a
NM_001376243.1 NP_001363172.1 E3 ubiquitin-protein ligase MARCHF7 isoform d
NM_001376244.1 NP_001363173.1 E3 ubiquitin-protein ligase MARCHF7 isoform e
NM_001376245.1 NP_001363174.1 E3 ubiquitin-protein ligase MARCHF7 isoform e
NM_001376246.1 NP_001363175.1 E3 ubiquitin-protein ligase MARCHF7 isoform f
NM_001376247.1 NP_001363176.1 E3 ubiquitin-protein ligase MARCHF7 isoform g
NM_001376248.1 NP_001363177.1 E3 ubiquitin-protein ligase MARCHF7 isoform g
NM_001376249.1 NP_001363178.1 E3 ubiquitin-protein ligase MARCHF7 isoform h
NM_001376250.1 NP_001363179.1 E3 ubiquitin-protein ligase MARCHF7 isoform h
NM_001376251.1 NP_001363180.1 E3 ubiquitin-protein ligase MARCHF7 isoform h
NM_001376252.1 NP_001363181.1 E3 ubiquitin-protein ligase MARCHF7 isoform h
NM_001376253.1 NP_001363182.1 E3 ubiquitin-protein ligase MARCHF7 isoform i
NM_001376254.1 NP_001363183.1 E3 ubiquitin-protein ligase MARCHF7 isoform i
NM_001376255.1 NP_001363184.1 E3 ubiquitin-protein ligase MARCHF7 isoform j
NM_022826.4 NP_073737.1 E3 ubiquitin-protein ligase MARCHF7 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MDM2/MDM4 family protein binding IPI
IPI: Inferred from physical interaction
29295817 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables ubiquitin conjugating enzyme binding IPI
IPI: Inferred from physical interaction
18410486 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
25552655 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
29295817 GOA
involved in negative regulation of cilium assembly IDA
IDA: Inferred from direct assay
25552655 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
29295817 GOA
involved in negative regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
29295817 GOA
involved in negative regulation of protein autoubiquitination IMP
IMP: Inferred from mutant phenotype
29295817 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
29295817 GOA
involved in positive regulation of protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
29295817 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
24905733 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
29295817 GOA
Cellular Component GO Annotation Evidence References Source
is active in centrosome IDA
IDA: Inferred from direct assay
25552655 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29295817 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARCHF7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MARCHF7 Q9H992 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
MARCHF7 Q9H992 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
MARCHF7 Q9H992 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
MARCHF7 Q9H992 MAPRE3 Homo sapiens Q9UPY8
Y2H Prey Pooling
32296183
Intra
MARCHF7 Q9H992 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction