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RNF182 - ring finger protein 182 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 221687

About RNF182

This gene has 8 transcripts (splice variants), 192 orthologues and 5 paralogues. Biased expression in brain (RPKM 4.5), bone marrow (RPKM 2.7) and 7 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNF182 Products (4)

mRNA	Protein	Name
NM_001165032.2	NP_001158504.1	E3 ubiquitin-protein ligase RNF182
NM_001165033.2	NP_001158505.1	E3 ubiquitin-protein ligase RNF182
NM_001165034.2	NP_001158506.1	E3 ubiquitin-protein ligase RNF182
NM_152737.4	NP_689950.1	E3 ubiquitin-protein ligase RNF182

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18298843	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	18298843	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	18298843	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18298843	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF182	RING-type E3 ubiquitin transferase RNF182

RNF182 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF182	Q8N6D2	UBE2N	Homo sapiens	P61088	Y2H Array	19690564

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12067	RNF182 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RNF182	VGNC	VGNC:34040
Rattus norvegicus	RNF182	RGD	RGD:1560399
Mus musculus	RNF182	MGD	MGI:3045355
Macaca mulatta	RNF182	VGNC	VGNC:76852
Felis catus	RNF182	VGNC	VGNC:102506
Others	RNF182	NCBI