7-Methyluric acid
Based on 1 Customer Validation
7-Methyluric acid is a methylated purine metabolite of Theobromine (HY-N0138) and Caffeine. 7-Methyluric acid is a substrate of OAT1 (SLC22A6) and OAT3 (SLC22A8). 7-Methyluric acid is not transported by OATP1B1, OATP1B3, OCT2, MATE1, or P-glycoprotein. 7-Methyluric acid can be used in studies on urolithiasis.
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- Pureza : 99.9%
- No. CAS: 612-37-3
- Fòrmula: C6H6N4O3
- Peso molecular:182.14
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
7-Methyluric acid (10-100 μM; 20 min) is a substrate of OAT1 in HEK-OAT1 cells[15].
7-Methyluric acid (100 μM; 20 min) does not show significant transport by OATP1B1, OATP1B3, OCT2, or MATE1 in HEK cells[15].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 612-37-3
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Appearance Solid
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Peso molecular 182.14
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Fòrmula C6H6N4O3
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Color White to off-white
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SMILES
O=C(NC(N1)=C2N(C)C1=O)NC2=O
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Structure Classification
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Initial Source
rat's urine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 20 mg/mL (109.81 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[2]. Safranow K, et al. Methylated purines in urinary stones. Clinical chemistry. 2005 Aug;51(8):1493-8.
[5]. Burg AW. Physiological disposition of caffeine. Drug metabolism reviews. 1975 Jan 1;4(2):199-228.
[10]. Damen J. Metabolome of healthy and unhealthy dietary patterns.
[12]. Aldridge A J. The effect of age and species on the metabolism of caffeine[J]. 1979.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4903 mL | 27.4514 mL | 54.9028 mL | 137.2571 mL |
| 5 mM | 1.0981 mL | 5.4903 mL | 10.9806 mL | 27.4514 mL | |
| 10 mM | 0.5490 mL | 2.7451 mL | 5.4903 mL | 13.7257 mL | |
| 15 mM | 0.3660 mL | 1.8301 mL | 3.6602 mL | 9.1505 mL | |
| 20 mM | 0.2745 mL | 1.3726 mL | 2.7451 mL | 6.8629 mL | |
| 25 mM | 0.2196 mL | 1.0981 mL | 2.1961 mL | 5.4903 mL | |
| 30 mM | 0.1830 mL | 0.9150 mL | 1.8301 mL | 4.5752 mL | |
| 40 mM | 0.1373 mL | 0.6863 mL | 1.3726 mL | 3.4314 mL | |
| 50 mM | 0.1098 mL | 0.5490 mL | 1.0981 mL | 2.7451 mL | |
| 60 mM | 0.0915 mL | 0.4575 mL | 0.9150 mL | 2.2876 mL | |
| 80 mM | 0.0686 mL | 0.3431 mL | 0.6863 mL | 1.7157 mL | |
| 100 mM | 0.0549 mL | 0.2745 mL | 0.5490 mL | 1.3726 mL |
7-Methyluric acid Related Classifications
HY-W016415 Related Classifications
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