612-37-3
612-37-3
Chemical Structure
7-Methyluric acid
- CAS No.: 612-37-3
- Formula:C6H6N4O3
- Molecular Weight:182.14
IUPAC Name: 7-methyl-7H-purine-2,6,8-triol
InChIKey: YHNNPKUFPWLTOP-UHFFFAOYSA-N
SMILES: O=C(NC(N1)=C2N(C)C1=O)NC2=O
Biological Activity: 7-Methyluric acid is a methylated purine metabolite of Theobromine (HY-N0138) and Caffeine. 7-Methyluric acid is a substrate of OAT1 (SLC22A6) and OAT3 (SLC22A8). 7-Methyluric acid is not transported by OATP1B1, OATP1B3, OCT2, MATE1, or P-glycoprotein. 7-Methyluric acid can be used in studies on urolithiasis[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7-Methyluric acid | 99.9% | 7-Methyluric acid is a methylated purine metabolite of Theobromine (HY-N0138) and Caffeine. 7-Methyluric acid is a substrate of OAT1 (SLC22A6) and OAT3 (SLC22A8). 7-Methyluric acid is not transported by OATP1B1, OATP1B3, OCT2, MATE1, or P-glycoprotein. 7-Methyluric acid can be used in studies on urolithiasis. | ||||||||||||||||||||
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References
- [1]. Shively CA, et al. High levels of methylxanthines in chocolate do not alter theobromine disposition. Clinical pharmacology and therapeutics. 1985 Apr;37(4):415-24.
- [2]. Safranow K, et al. Methylated purines in urinary stones. Clinical chemistry. 2005 Aug;51(8):1493-8.
- [3]. Arnaud MJ, et al. Metabolic pathway of theobromine in the rat and identification of two new metabolites in human urine. Journal of Agricultural and Food Chemistry. 1979 May;27(3):524-7.
- [4]. Shively CA, et al. Diet-induced alterations in theobromine disposition and toxicity in the rat. Toxicology and applied pharmacology. 1986 Jul;84(3):593-8.
- [5]. Burg AW. Physiological disposition of caffeine. Drug metabolism reviews. 1975 Jan 1;4(2):199-228.
- [6]. Shively CA, et al. Theobromine metabolism and pharmacokinetics in pregnant and nonpregnant Sprague-Dawley rats. Toxicology and applied pharmacology. 1983 Mar 15;67(3):376-82.
- [7]. Safranow K, et al. Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 May 25;819(2):229-35.
- [8]. Dutrieu J, et al. Evaluation of a new kit for the determination of 3-methoxy-4-hydroxymandelic acid (VMA) by liquid chromatography and electrochemical detection (LCEC). Fresenius' Zeitschrift für analytische Chemie. 1984 Jan;319(1):70-3.
- [9]. Nguyen NT. ELECTROCHEMICAL AND ENZYMATIC OXIDATION OF TRYPTOPHAN AND 7-METHYLURIC ACID AND SPECTROELECTROCHEMICAL SEARCH FOR A TERTIARY ALCOHOL INTERMEDIATE IN THE ELECTROCHEMICAL OXIDATION OF URIC ACID. The University of Oklahoma; 1985.
- [10]. Damen J. Metabolome of healthy and unhealthy dietary patterns.
- [11]. Weinfeld H, et al. The metabolism of caffeine and theophylline. J. biol. Chem. 1953 Jan 1;200:345-55.
- [12]. Aldridge A J. The effect of age and species on the metabolism of caffeine[J]. 1979.
- [13]. Szczawinska K, et al. Caffeine does not bind covalently to liver microsomes from different animal species and to proteins and DNA from perfused rat liver. Chemico-biological interactions. 1981 Mar 15;34(3):345-54.
- [14]. Picurová J, et al. In vitro transporter substrate properties of previously reported biomarkers for renal OAT1/OAT3-mediated drug-drug interactions. Biochemical pharmacology. 2025 Nov;241:117184.
- [15]. Gessner A, et al. New Biomarkers for Renal Transporter-Mediated Drug-Drug Interactions: Metabolomic Effects of Cimetidine, Probenecid, Verapamil, and Rifampin in Humans. Clinical pharmacology and therapeutics. 2025 Jan;117(1):130-142.
