ANO1-IN-2
ANO1-IN-2 (Compound 10q) is a selective ANO1 channel blocker with an IC50 of 1.75 μM and 7.43 μM against ANO1 and ANO2, respectively. ANO1-IN-2 suppresses strongly proliferation of glioblastoma cells.
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- No. CAS: 637314-12-6
- Fòrmula: C16H14ClN3O2S2
- Peso molecular:379.88
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 1.75 μM (ANO1), 7.43 μM (ANO2)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Astrocyte | GI50 |
45.15 μM
Compound: 10q
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Antiproliferative activity against mouse primary astrocytes assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent assay
Antiproliferative activity against mouse primary astrocytes assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent assay
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[PMID: 32906067] |
| U138-MG | GI50 |
13.22 μM
Compound: 10q
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Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
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[PMID: 32906067] |
| U-251 | GI50 |
12.04 μM
Compound: 10q
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Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
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[PMID: 32906067] |
| U-87MG ATCC | GI50 |
23.77 μM
Compound: 10q
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Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
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[PMID: 32906067] |
In Vitro
ANO1-IN-2 (Compound 10q) (10 μM) significantly suppresses migration and invasion of U251 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 637314-12-6
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Peso molecular 379.88
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Fòrmula C16H14ClN3O2S2
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SMILES
NC(C1=C(SC2=C1CCC2)NC(NC(C3=CC=C(C=C3)Cl)=O)=S)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ANO1-IN-2 Related Classifications
HY-146321 Related Classifications
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