country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-162041

Copy Link Print Information

AQIM-I

AQIM-I is an inhibitor of survivin via inhibits survivin expression and colony formation. AQIM-I induces ROS production, apoptosis, cell cycle arrest, DNA damage, and autophagy. AQIM-I inhibits nonsmall cell lung cancer cells A549 with an IC₅₀ value of 9 nM.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2247881-73-6
Fòrmula: C₁₇H₁₃IN₂O₂
Peso molecular:404.20

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AQIM-I Chemical Structure

No. CAS: 2247881-73-6

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
143B	IC₅₀	0.59 μM Compound: 60; AQIM-I	Antiproliferative activity against human 143B cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human 143B cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
5637	IC₅₀	0.18 μM Compound: 60; AQIM-I	Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human 5637 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
A549	IC₅₀	0.009 μM Compound: 60; AQIM-I	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs in presence of scramble siRNA by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 48 hrs in presence of scramble siRNA by MTT assay	[PMID: 38079530]
A549	IC₅₀	0.98 μM Compound: 60; AQIM-I	Antiproliferative activity against survivin silenced human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against survivin silenced human A549 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
ASPC1	IC₅₀	0.25 μM Compound: 60; AQIM-I	Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human ASPC1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
BXPC-3	IC₅₀	0.07 μM Compound: 60; AQIM-I	Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
HeLa	IC₅₀	1.16 μM Compound: 60; AQIM-I	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
HepG2	IC₅₀	0.25 μM Compound: 60; AQIM-I	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
HUVEC	IC₅₀	6.66 μM Compound: 60; AQIM-I	Antiproliferative activity against human HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
MCF7	IC₅₀	0.06 μM Compound: 60; AQIM-I	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
MRC5	IC₅₀	6.9 μM Compound: 60; AQIM-I	Antiproliferative activity against human MRC5 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MRC5 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
NCI-H1299	IC₅₀	0.51 μM Compound: 60; AQIM-I	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
NCI-H460	IC₅₀	0.14 μM Compound: 60; AQIM-I	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
NIH3T3	IC₅₀	14 μM Compound: 60; AQIM-I	Antiproliferative activity against mouse NIH3T3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against mouse NIH3T3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
PANC-1	IC₅₀	0.08 μM Compound: 60; AQIM-I	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]
TE-1	IC₅₀	0.05 μM Compound: 60; AQIM-I	Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38079530]

Chemical Information

No. CAS 2247881-73-6
Peso molecular 404.20
Fòrmula C₁₇H₁₃IN₂O₂
SMILES

O=C1C2=C(C(C3=CC4=C(C=C31)C=CC=C4)=O)N(C=[N+]2C)C.[I-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Jing Yuan, et al. Pioneering 4,11-Dioxo-4,11-dihydro-1 H-anthra[2,3- d]imidazol-3-ium Compounds as Promising Survivin Inhibitors by Targeting ILF3/NF110 for Cancer Therapy. J Med Chem. 2023. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto