Dezaguanine
Dezaguanine is a purine analog. Dezaguanine exhibits antitumor activity in leukemia and breast cancer cells. Dezaguanine can be used in cancer-related research.
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- No. CAS: 41729-52-6
- Fòrmula: C6H6N4O
- Peso molecular:150.14
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AA6 | MIC |
0.5 mM
Compound: 1
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Ability to inhibit growth of AA-6 cells (a mutant cell line resistant to 8-azaadenine and lacks adenine phosphoryltransferase) was determined
Ability to inhibit growth of AA-6 cells (a mutant cell line resistant to 8-azaadenine and lacks adenine phosphoryltransferase) was determined
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[PMID: 6438321] |
| CV-1 | CC50 |
250 μM
Compound: 3-deazaguanine
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Cytotoxicity against African green monkey CV1 cells
Cytotoxicity against African green monkey CV1 cells
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[PMID: 26260336] |
| CV-1 | IC50 |
4.1 μM
Compound: 3-deazaguanine
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Antiviral activity against Measles virus infected in African green monkey CV1 cells after 3 days by neutral red dye-based plaque reduction assay
Antiviral activity against Measles virus infected in African green monkey CV1 cells after 3 days by neutral red dye-based plaque reduction assay
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[PMID: 26260336] |
| L1210 | ED50 |
11 μM
Compound: 3-deazaguanine
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Effective dose that produced 50% inhibition of L1210 Leukemia cell growth in culture
Effective dose that produced 50% inhibition of L1210 Leukemia cell growth in culture
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[PMID: 6827548] |
| MOLT-4 | IC50 |
3.7 μM
Compound: 1
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Compound was tested for inhibition of MOLT-4 cell growth using human lymphoblast cytotoxicity assay in the absence of 2''-deoxy guanosine, cytotoxicity determined by monitoring uptake of [3H]thymidine
Compound was tested for inhibition of MOLT-4 cell growth using human lymphoblast cytotoxicity assay in the absence of 2''-deoxy guanosine, cytotoxicity determined by monitoring uptake of [3H]thymidine
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[PMID: 3093681] |
| MOLT-4 | IC50 |
5.9 μM
Compound: 1
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Compound was tested for inhibition of MOLT-4 cell growth using human lymphoblast cytotoxicity assay in the presence of 2''-deoxy guanosine, cytotoxicity determined by monitoring uptake of [3H]thymidine
Compound was tested for inhibition of MOLT-4 cell growth using human lymphoblast cytotoxicity assay in the presence of 2''-deoxy guanosine, cytotoxicity determined by monitoring uptake of [3H]thymidine
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[PMID: 3093681] |
Dezaguanine (0.1-150 μg/mL) inhibits virus-induced cytopathic effects in primary rabbit kidney cells, Vero cells and HeLa cells, with an IC50 range of 0.1 to 150 μg/mL against all tested viruses[1].
Dezaguanine (0.01-1.50 mM; 7 days) inhibits the growth of wild-type CHO cells, APRT-deficient CHO AAR-6a cells, and HGPRT-deficient CHO TGR-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Wild-type CHO cells, APRTase-deficient CHO AAR-6a cells, HGPRTase-deficient CHO TGR-1 cells
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Concentration:0.01 mM; 0.50 mM; 1.50 mM
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Incubation Time:7 days
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Result:Inhibited growth with a minimum inhibitory concentration of 0.01 mM in wild-type CHO cells.
Inhibited growth with a minimum inhibitory concentration of 0.50 mM in APRTase-deficient CHO AAR-6a cells.
Inhibited growth with a minimum inhibitory concentration of 1.50 mM in HGPRTase-deficient CHO TGR-1 cells.
Dezaguanine (17-270 mg/kg; intravenous injection; single dose/5 consecutive days) only causes mild gastrointestinal reactions in Beagle dogs at a single intravenous dose of 270 mg/kg, whereas the 17 mg/kg dose administered intravenously for 5 consecutive days is lethal[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Beagle[2]
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Dosage:270 mg/kg (single i.v. dose); 17 mg/kg/day (5-day daily i.v. dose)
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Administration:i.v. (single dose; daily; 5 consecutive days)
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Result:Caused only mild emesis and anorexia, with no detectable organ toxicities via biochemical or histological evaluation (single i.v. 270 mg/kg dose).
Was lethal, with death secondary to necrotizing enteritis and myelosuppression (5-day daily i.v. 17 mg/kg dose).
Chemical Information
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No. CAS 41729-52-6
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Peso molecular 150.14
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Fòrmula C6H6N4O
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SMILES
O=C1NC(N)=CC=2NC=NC12
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dezaguanine Related Classifications
HY-105136A Related Classifications
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