Factor B-IN-8
Factor B-IN-8 (Compound (3R ,4R )-15) is a potent, selective and orally active factor B inhibitor with an IC50 of 10.2 nM. Factor B-IN-8 can effectively inhibit the binding of factor B to C3b and the subsequent formation of C3 convertase (C3bBb). Factor B-IN-8 can inhibit the deposition of membrane attack complex (MAC) mediated by alternativepathway with an IC50 of 59.3 nM. Factor B-IN-8 can reduce the cleavage of factor B protein and decrease the deposition of complement C3d in the glomeruli and renal tubules. Factor B-IN-8 can be used for researches of arthritis and paroxysmal nocturnal hemoglobinuria (PNH).
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- No. CAS: 3049710-19-9
- Fòrmula: C24H25F3N2O4
- Peso molecular:462.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
| Species | Dose | Route | T1/2 | Cmax | AUC0-t | AUC0-∞ | Vss | Tmax | F |
|---|---|---|---|---|---|---|---|---|---|
| Dog[1] | 3 mg/kg | i.v. | 3.16 h | 14947 ng/mL | 8333 ng·h/mL | 9487 ng·h/mL | 1.23 L/kg | / | / |
| Dog[1] | 6 mg/kg | i.g. | 5.83 h | 4680 ng/mL | 14388 ng·h/mL | 16738 ng·h/mL | / | 0.46 h | 86.77 % |
| Rat[1] | 10 mg/kg | i.v. | 10.58 h | 16788 ng/mL | 11413 ng·h/mL | 15313 ng·h/mL | 9.18 L/kg | / | / |
| Rat[1] | 20 mg/kg | i.g. | 9.28 h | 2659 ng/mL | 8793 ng·h/mL | 13505 ng·h/mL | / | 0.38 h | 51.82 % |
Chemical Information
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No. CAS 3049710-19-9
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Peso molecular 462.46
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Fòrmula C24H25F3N2O4
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SMILES
CC(C=C1OC)=C(NC=C2)C2=C1O[C@H]3[C@H](C4=CC=C(C=C4)C(O)=O)CN(CC3)CC(F)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Factor B-IN-8 Related Classifications
HY-181040 Related Classifications
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