JMV-1645
JMV-1645 is a potent and selective B1 bradykinin receptor antagonist with a Ki value of 0.023 nM on the human cloned B1 receptor. JMV-1645 can be utilized in trauma and infection research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 284037-77-0
- Fòrmula: C49H69N13O12S
- Peso molecular:1064.22
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas Bradykinin Receptor
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Actividad biológica
Descripciòn
IC50 & Target
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Bradykinin B1 Receptor (B1R) 0.023 nM (Ki) |
Chemical Information
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No. CAS 284037-77-0
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Peso molecular 1064.22
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Fòrmula C49H69N13O12S
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Sequence
H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH
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Sequence Shortening
H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JMV-1645 Related Classifications
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