Nateglinide-d5
Based on 1 Customer Validation
Nateglinide-d5 is a deuterium labeled Nateglinide. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2].
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.0%
- No. CAS: 1227666-13-8
- Fòrmula: C19H22D5NO3
- Peso molecular:322.45
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
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DPP-4 |
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1227666-13-8
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Unlabeled CAS 105816-04-4
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Appearance Solid
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Peso molecular 322.45
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Fòrmula C19H22D5NO3
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Color White to off-white
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SMILES
O=C(O)[C@@H](CC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])NC([C@H]2CC[C@H](C(C)C)CC2)=O
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Synonyms
A4166 d5; Senaglinide d5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (310.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Christopher J. Dunn, et al. Nateglinide. OFILE Drugs 2000 Sep: 60 (3): 6.
[3]. Jian Luo, et al. Evaluating insulin secretagogues in a humanized mouse model with functional human islets. Metabolism. 2013 Jan;62(1):90-9. [Content Brief]
[4]. Duffy NA, et al. Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1. Eur J Pharmacol. 2007 Jul 30;568(1-3):278-86. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1013 mL | 15.5063 mL | 31.0126 mL | 77.5314 mL |
| 5 mM | 0.6203 mL | 3.1013 mL | 6.2025 mL | 15.5063 mL | |
| 10 mM | 0.3101 mL | 1.5506 mL | 3.1013 mL | 7.7531 mL | |
| 15 mM | 0.2068 mL | 1.0338 mL | 2.0675 mL | 5.1688 mL | |
| 20 mM | 0.1551 mL | 0.7753 mL | 1.5506 mL | 3.8766 mL | |
| 25 mM | 0.1241 mL | 0.6203 mL | 1.2405 mL | 3.1013 mL | |
| 30 mM | 0.1034 mL | 0.5169 mL | 1.0338 mL | 2.5844 mL | |
| 40 mM | 0.0775 mL | 0.3877 mL | 0.7753 mL | 1.9383 mL | |
| 50 mM | 0.0620 mL | 0.3101 mL | 0.6203 mL | 1.5506 mL | |
| 60 mM | 0.0517 mL | 0.2584 mL | 0.5169 mL | 1.2922 mL | |
| 80 mM | 0.0388 mL | 0.1938 mL | 0.3877 mL | 0.9691 mL | |
| 100 mM | 0.0310 mL | 0.1551 mL | 0.3101 mL | 0.7753 mL |
Nateglinide-d5 Related Classifications
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