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Referencia número: HY-162427

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NMS-0963

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC₅₀ value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM.

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No. CAS: 2765304-82-1
Fòrmula: C₂₃H₂₉N₇O₃
Peso molecular:451.52

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NMS-0963 Chemical Structure

No. CAS: 2765304-82-1

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC₅₀ value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	27 nM Compound: 1; NMS-0963	Antiproliferative activity against mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay	[PMID: 38604095]
BaF3	IC₅₀	7827 nM Compound: 1; NMS-0963	Antiproliferative activity against IL3 stimulated mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay Antiproliferative activity against IL3 stimulated mouse BaF3 cells harboring TEL/SYK incubated for 72 hrs by CellTiter-Glo assay	[PMID: 38604095]
SU-DHL-6	IC₅₀	702.4 nM Compound: 1; NMS-0963	Antiproliferative activity against human SU-DHL-6 cells incubated for 72 hrs by Celltiter-Glo based assay Antiproliferative activity against human SU-DHL-6 cells incubated for 72 hrs by Celltiter-Glo based assay	[PMID: 38604095]

Chemical Information

No. CAS 2765304-82-1
Peso molecular 451.52
Fòrmula C₂₃H₂₉N₇O₃
SMILES

CN1C(C(N[C@@H](C)CN2CCC2)=O)=CC(C3=CC=NC(NC4=CC(OC)=CC(OC)=C4)=N3)=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Giovanni Cervi, et al. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors. Eur J Med Chem. 2024. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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