Peresolimab
Based on 1 publication(s) in Google Scholar
Peresolimab is a humanized IgG1-κ antibody targeting to PD-1. Peresolimab potentially stimulates physiological immune inhibitory pathways to restore immune homeostasis. Peresolimab can be used in research of rheumatoid arthritis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.62%
- No. CAS: 2411580-63-5
- Peso molecular:145.16 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Peresolimab
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Actividad biológica
Human IgG1 kappa
Human
PDCD1/PD-1/CD279
Peresolimab is an agonist for PD-1 that binds to PD-1 receptor and activates PD-1 signaling pathway. Peresolimab inhibits T cell receptor (TCR) signals, inhibits the activation of T cells, thereby reducing inflammation and disease symptoms[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized PD-1 Protein, Cynomolgus can bind Peresolimab. The EC50 for this effect is 7.388 ng/mL.
Chemical Information
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No. CAS 2411580-63-5
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Appearance Liquid
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Peso molecular 145.16 kDa
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Color Colorless to light yellow
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SMILES
[Peresolimab]
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Synonyms
LY-3462817
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Pureza y Documentación
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Ficha de datos (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
[1]. Tuttle J, et al. Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis. Reply. N Engl J Med. 2023 Jul 27;389(4):378-379. [Content Brief]
[2]. Leane CM, et al., PD-1 regulation of pathogenic IL-17-secreting γδ T cells in experimental autoimmune encephalomyelitis. Eur J Immunol. 2024 Oct;54(10):e2451212. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)