Pifithrin-β
Based on 21 publication(s) in Google Scholar
Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 60477-34-1
- Fòrmula: C16H16N2S
- Peso molecular:268.38
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Publications Citing Use of MedChemExpress (MCE) Pifithrin-β
More- Nat Commun. 2025 Feb 25;16(1):1774. [Abstract]
- J Immunother Cancer. 2026 Feb 24;14(2):e013655. [Abstract]
- Cell Commun Signal. 2022 Sep 5;20(1):96. [Abstract]
- Int J Mol Med. 2021 Jul;48(1):122. [Abstract]
- Cancer Cell Int. 2023 Sep 28;23(1):221. [Abstract]
- Life Sci. 2021 Sep 1:280:119698. [Abstract]
- Front Bioeng Biotechnol. 2020 Feb 20:8:75. [Abstract]
- Cell Biol Toxicol. 2023 Oct;39(5):2011-2032. [Abstract]
- Int J Mol Sci. 2023 Jul 17;24(14):11554. [Abstract]
- mBio. 2024 Dec 11;15(12):e0213724. [Abstract]
- Front Cell Dev Biol. 2020 Jul 29:8:703. [Abstract]
- Sci Rep. 2025 Sep 29;15(1):33534. [Abstract]
- iScience. 2024 Jun 4;27(7):110144. [Abstract]
- Front Mol Biosci. 2021 Aug 19;8:697457. [Abstract]
- FASEB J. 2021 Feb;35(2):e21325. [Abstract]
- J Virol. 2025 Aug 29:e0052925. [Abstract]
- Cell Biol Int. 2025 Jul;49(7):852-864. [Abstract]
- PLoS One. 2018 Sep 20;13(9):e0203833. [Abstract]
- Blood Cells Mol Dis. 2024 Jan:104:102798. [Abstract]
- bioRxiv. 2025 March 21.
- Heliyon. 2024 May 20;10(11):e31431. [Abstract]
Customer Validation & Images
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 23 μM (p53)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IGROV-1 | IC50 |
23 μM
Compound: PFT-beta
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Antiproliferative activity against human IGROV1 cells after 72 hrs by cell counter
Antiproliferative activity against human IGROV1 cells after 72 hrs by cell counter
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[PMID: 21324703] |
In Vitro
Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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No. CAS 60477-34-1
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Appearance Solid
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Peso molecular 268.38
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Fòrmula C16H16N2S
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Color White to off-white
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SMILES
CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
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Synonyms
PFT β; Cyclic Pifithrin-α
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (21)
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Journal Impact Factor
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Most Recent
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Nat Commun
Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation. [Abstract]2025 Feb 25;16(1):1774. PMID: 40000627 -
J Immunother Cancer
Macrophage Mtdh deficiency discordantly regulated tumor growth and metastasis through increased thrombospondin-1 production. [Abstract]2026 Feb 24;14(2):e013655. PMID: 41734995 -
Cell Commun Signal
Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1. [Abstract]2022 Sep 5;20(1):96. PMID: 36058938 -
Int J Mol Med
Isoquercitrin protects HUVECs against high glucose‑induced apoptosis through regulating p53 proteasomal degradation. [Abstract]2021 Jul;48(1):122. PMID: 33982778 -
Cancer Cell Int
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53. [Abstract]2023 Sep 28;23(1):221. PMID: 37770925 -
Life Sci
Inhibition of miR-431-5p attenuated liver apoptosis through KLF15/p53 signal pathway in S100 induced autoimmune hepatitis mice. [Abstract]2021 Sep 1:280:119698. PMID: 34111466 -
Front Bioeng Biotechnol
MiR-29c-3p Suppresses the Migration, Invasion and Cell Cycle in Esophageal Carcinoma via CCNA2/p53 Axis. [Abstract]2020 Feb 20:8:75. PMID: 32154226 -
Cell Biol Toxicol
USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. [Abstract]2023 Oct;39(5):2011-2032. PMID: 35022897 -
Int J Mol Sci
Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis. [Abstract]2023 Jul 17;24(14):11554. PMID: 37511311 -
mBio
2024 Dec 11;15(12):e0213724. PMID: 39475231 -
Front Cell Dev Biol
2020 Jul 29:8:703. PMID: 32850823 -
Sci Rep
IL6/STAT3 induced GRWD1 mediates aerobic glycolysis via P53/GLUT1 signal axis in colon carcinoma. [Abstract]2025 Sep 29;15(1):33534. PMID: 41022893 -
iScience
2024 Jun 4;27(7):110144. PMID: 38989466 -
Front Mol Biosci
2021 Aug 19;8:697457. PMID: 34490348 -
FASEB J
2021 Feb;35(2):e21325. PMID: 33508145 -
J Virol
2025 Aug 29:e0052925. PMID: 40879372 -
Cell Biol Int
2025 Jul;49(7):852-864. PMID: 40329699 -
PLoS One
2018 Sep 20;13(9):e0203833. PMID: 30235236
Pifithrin-β purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Sep 20;13(9):e0203833. [Abstract]
Western Blot analysis of TFDP3, p53 and LC3 in whole cell lysates of MDA-MB-231 transfected and treated with indicated plasmids and reagents. Cells in the treatment group are incubated with 20 μM PFT-beta for 24 hours.
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Blood Cells Mol Dis
2024 Jan:104:102798. PMID: 37813040 -
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Heliyon
HMGA2 promotes resistance against paclitaxel by targeting the p53 signaling pathway in colorectal cancer cells. [Abstract]2024 May 20;10(11):e31431. PMID: 38845972
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. [Content Brief]
[2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pifithrin-β Related Classifications
HY-16702 Related Classifications
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