Gemcitabine monophosphate disodium
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles.
For research use only. We do not sell to patients.
- CAS No.: 1638288-31-9
- Formula: C9H10F2N3Na2O7P
- Molecular Weight:387.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1]
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Dosage:19.5 mg/kg, every other day, four injections
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Administration:Intravenous injection (i.v.)
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Result:Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis.
Chemical Information
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CAS No. 1638288-31-9
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Molecular Weight 387.14
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Formula C9H10F2N3Na2O7P
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SMILES
O=P(O[Na])(O[Na])OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C=CC(N)=NC2=O)O1
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Synonyms
Gemcitabine 5′-phosphate disodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. [Content Brief]
[2]. Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gemcitabine monophosphate disodium Related Classifications
HY-108932A Related Classifications
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