Abr - active BCR-related gene Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109934

Summary

Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including neuromuscular process controlling balance; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Located in cytosol; glutamatergic synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; mesothelium; metanephros; nervous system; and sensory organ. Orthologous to human ABR (ABR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Abr Products (6)

mRNA Protein Name
NM_001291186.2 NP_001278115.1 active breakpoint cluster region-related protein isoform 4
NM_001346670.2 NP_001333599.1 active breakpoint cluster region-related protein isoform 5
NM_001363379.2 NP_001350308.1 active breakpoint cluster region-related protein isoform 6
NM_198018.3 NP_932135.1 active breakpoint cluster region-related protein isoform 1
NM_198894.3 NP_942597.1 active breakpoint cluster region-related protein isoform 2
NM_198895.3 NP_942598.1 active breakpoint cluster region-related protein isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
17116687 MGI
enables GTPase activator activity IGI
IGI: Inferred from genetic interaction
19703997 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
11684658 MGI
acts upstream of cell migration IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of establishment of localization in cell IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
11921339 MGI
acts upstream of macrophage migration IGI
IGI: Inferred from genetic interaction
17116687 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
20962234 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
20962234 MGI
involved in negative regulation of blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
23152932 MGI
involved in negative regulation of cellular extravasation IMP
IMP: Inferred from mutant phenotype
23152932 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
19703997 MGI
acts upstream of or within negative regulation of macrophage migration IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within negative regulation of neutrophil degranulation IGI
IGI: Inferred from genetic interaction
19703997 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: Inferred from genetic interaction
11921339 MGI
acts upstream of neutrophil degranulation IGI
IGI: Inferred from genetic interaction
19703997 MGI
acts upstream of phagocytosis IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within positive regulation of phagocytosis IGI
IGI: Inferred from genetic interaction
17116687 MGI
involved in regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
23152932 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19703997 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
20962234 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
20962234 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17116687 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20962234 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20962234 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17116687 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

active breakpoint cluster region-related protein

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13010 Laquinimod 99.46% Yes

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-10528 Tasquinimod Modulator 99.70% Phase 3
HY-13743 Roquinimex Inhibitor 99.69% Phase 3
HY-W062904 Laquinimod sodium Inhibitor / Phase 3
HY-13743R Roquinimex (Standard) Inhibitor / Phase 3
HY-100442 Paquinimod Inhibitor 99.90% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141537 ABR-238901 Inhibitor 98.92% Unkown
HY-100442S1 Paquinimod-d5-1 Inhibitor 98.19% Unkown
HY-10528S Tasquinimod-d3 Modulator 99.34% Unkown
HY-13010S Laquinimod-d5 Inhibitor 98.25% Unkown
HY-RS00110 ABR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100442S Paquinimod-d5 Inhibitor / Unkown
HY-RS17572 Abr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24032 Abr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99436 Anatumomab mafenatox Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abr NCBI NCBI:29
Macaca fascicularis Abr NCBI NCBI:102126046
Rattus norvegicus Abr NCBI NCBI:287537