KIR3DL3 - killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 Gene

Also Known as KIR44; KIRC1; CD158Z; KIR3DL7; KIR2DL5B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115653

About KIR3DL3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,724,442-54,736,632 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 68 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]

KIR3DL3 Products (1)

mRNA Protein Name
NM_153443.5 NP_703144.3 killer cell immunoglobulin-like receptor 3DL3 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIR3DL3 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 117)

Ig_3

Ig_3: Immunoglobulin domain (123 - 198)

ig

ig: Immunoglobulin domain (237 - 294)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

killer cell immunoglobulin-like receptor 3DL3

  • CD158 antigen-like family member Z

KIR3DL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KIR3DL3 Q8N743 SLC41A2 Homo sapiens Q96JW4
Validated Y2H
32296183
Intra
KIR3DL3 Q8N743 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
KIR3DL3 Q8N743 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra
KIR3DL3 Q8N743 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
KIR3DL3 Q8N743 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
Intra
KIR3DL3 Q8N743 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra
KIR3DL3 Q8N743 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KIR3DL3 Proteins

Cat. No. Product Name Accession Purity
HY-P77042 KIR3DL3/CD158z Protein, Human (HEK293, His) Q8N743/NP_703144.2 (Q26-L322) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78167 KIR3DL3/CD158z Protein, Human (Biotinylated, HEK293, His-Avi) Q8N743 (E26-L322) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78475 KIR3DL3/CD158z Protein, Human (HEK293, His-Avi) Q8N743 (E26-L322) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Duane Retraction Syndrome

  • Stilling-Turk-Duane Syndrome

  • Duane'S Syndrome

  • Duane Syndrome

  • Isolated Duane Retraction Syndrome

  • Co-Contractive Retraction Syndrome

  • Duane Anomaly, Isolated

  • Ocular Retraction Syndrome

  • Drs

  • Durs
Maxillary Sinus Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Maxillary Sinus

  • Adenoid Cystic Carcinoma Of The Maxillary Sinus
Chronic Nk-Cell Lymphocytosis

  • Nk-Cell Large Granular Lymphocyte Lymphocytosis

  • Chronic Lymphoproliferative Disorder Of Nk-Cells
Amelogenesis Imperfecta, Type Ie

  • Aih1

  • Amelogenesis Imperfecta Type 1e

  • AI1E

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

  • Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

  • Enamel Hypoplasia, X-Linked

  • Amelogenesis Imperfecta Type Ie

  • Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

  • Enamel Hypoplasia X-Linked

  • Amelogenesis Imperfecta, X-Linked 1

  • Amelogenesis Imperfecta, Type 1e

  • Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

  • X-Linked Amelogenesis Imperfecta 1

  • X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

  • X-Linked Enamel Hypoplasia

  • Amelogenesis Imperfecta X-Linked 1

  • Amelogenesis Imperfecta 1e

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

  • Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

  • Xai

  • X-Linked Amelogenesis Imperfecta

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07310 KIR3DL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown