BPIFA2 - BPI fold containing family A member 2 Gene

Also Known as PSP; SPLUNC2; C20orf70; bA49G10.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140683

About BPIFA2

This gene has 2 transcripts (splice variants), 89 orthologues and 12 paralogues. Restricted expression toward salivary gland (RPKM 1129.7).

Summary

This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local Antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds Bacterial lipopolysaccharide (LPS) and inhibits Bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

BPIFA2 Products (2)

mRNA Protein Name
NM_001319164.2 NP_001306093.1 BPI fold-containing family A member 2 precursor
NM_080574.4 NP_542141.1 BPI fold-containing family A member 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
21833535 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
19499239 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
28775000 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BPIFA2 Protein Structure

LBP_BPI_CETP

LBP_BPI_CETP: LBP / BPI / CETP family, N-terminal domain (62 - 227)

  • 0
  • 100
  • 200
  • 249 a.a.
Protein Preferred Names Protein Names

BPI fold-containing family A member 2

  • parotid secretory protein

BPIFA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BPIFA2 Q96DR5 CMTM6 Homo sapiens Q9NX76
Y2H Array
32296183
Intra
BPIFA2 Q96DR5 CMTM6 Homo sapiens Q9NX76
Y2H Prey Pooling
32296183
Intra
BPIFA2 Q96DR5 CMTM6 Homo sapiens Q9NX76
Validated Y2H
32296183
Intra
BPIFA2 Q96DR5 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
BPIFA2 Q96DR5 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
BPIFA2 Q96DR5 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BPIFA2 Proteins

Cat. No. Product Name Accession Purity
HY-P76749 BPIFA2 Protein, Human (HEK293, Fc) Q96DR5 (E19-I249) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76750 BPIFA2 Protein, Human (HEK293, His) Q96DR5 (E19-I249) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Papillary Cystadenocarcinoma

  • Cystadenocarcinoma, Papillary
Xerophthalmia

  • Conjunctival Xerosis
Parotid Disease

  • Parotid Diseases
Lacrimal Apparatus Disease

  • Lacrimal Apparatus Diseases
Filamentary Keratitis
Sialadenitis

  • Sialoadenitis

  • Adenitis, Salivary Gland

  • Salivary Gland Inflammation

  • Salivary Gland Adenitis

  • Sialitis

  • Inflammation Of Salivary Gland

  • Inflammation Of Salivary Duct Or Gland

  • Salivary Glandular Adenitis

  • Sialoangiitis

  • Sialoangitis

  • Sialodochitis
Parotitis
Dry Eye Syndrome

  • Dry Eye Syndromes

  • Dry Eye Disease

  • Tear Film Insufficiency

  • Xerophthalmia
Lagophthalmos

  • Defective Lid Closure

  • Poor Closure Eyelids
Keratoconjunctivitis Sicca

  • Kcs

  • Dry Eye Syndromes

  • Keratitis Sicca

  • Xerophthalmia
Dacryoadenitis

  • Dacryocystitis
Autoimmune Disease Of Exocrine System
Potocki-Shaffer Syndrome

  • Proximal 11p Deletion Syndrome

  • Chromosome 11p11.2 Deletion Syndrome

  • Pss

  • 11p11.2 Deletion

  • P11pds

  • Defect11 Syndrome

  • Deletion Of Chromosome 11p11.2

  • POSHS
Salivary Gland Disease

  • Salivary Gland Disorders

  • Salivary Gland Diseases

  • Non-Neoplastic Salivary Gland Disease

  • Non-Neoplastic Salivary Gland Disorder

  • Disorder Of Salivary Gland

  • Lesion Of Salivary Gland Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01582 BPIFA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20139 Bpifa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26642 Bpifa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BPIFA2 VGNC VGNC:107773
Rattus norvegicus BPIFA2 RGD RGD:3431
Mus musculus BPIFA2 MGD MGI:97787
Canis familiaris BPIFA2 VGNC VGNC:38505
Others BPIFA2 NCBI