DLST - dihydrolipoamide S-succinyltransferase Gene

Also Known as DLTS; KGD2; PGL7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1743

About DLST

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:74,881,916-74,903,743 (from NCBI)

This gene has 16 transcripts (splice variants), 267 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 40.7), heart (RPKM 35.9) and 25 other tissues.

Summary

This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

DLST Products (2)

mRNA Protein Name
NM_001244883.2 NP_001231812.1 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor
NM_001933.5 NP_001924.2 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor
Molecular Function GO Annotation Evidence Verweise Source
enables acyltransferase activity IMP
IMP: Inferred from mutant phenotype
30929736 GOA
enables dihydrolipoyllysine-residue succinyltransferase activity IMP
IMP: Inferred from mutant phenotype
30929736 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in tricarboxylic acid cycle IMP
IMP: Inferred from mutant phenotype
30929736 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrion IDA
IDA: Inferred from direct assay
29211711 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29211711 GOA
part of oxoadipate dehydrogenase complex IDA
IDA: Inferred from direct assay
29191460 GOA
part of oxoglutarate dehydrogenase complex IDA
IDA: Inferred from direct assay
29211711 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLST Protein Structure

Biotin_lipoyl

Biotin_lipoyl: Biotin-requiring enzyme (72 - 143)

2-oxoacid_dh

2-oxoacid_dh: 2-oxoacid dehydrogenases acyltransferase (catalytic domain) (222 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

  • E2K

DLST Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DLST P36957 KIAA1683 Homo sapiens A0JP07 32814053
Intra
DLST P36957 KIAA1683 Homo sapiens A0JP07 32814053
Intra
DLST P36957 KIAA1683 Homo sapiens A0JP07 32814053
Intra
DLST P36957 CAMTA2 Homo sapiens O94983-5 32814053
Intra
DLST P36957 CAMTA2 Homo sapiens O94983-5 32814053
Intra
DLST P36957 CAMTA2 Homo sapiens O94983-5 32814053
Intra
DLST P36957 EVA1B Homo sapiens Q9NVM1 32814053
Intra
DLST P36957 EVA1B Homo sapiens Q9NVM1 32814053
Intra
DLST P36957 EVA1B Homo sapiens Q9NVM1 32814053
Intra
DLST P36957 TPX2 Homo sapiens Q9ULW0 32814053
Intra
DLST P36957 TPX2 Homo sapiens Q9ULW0 32814053
Intra
DLST P36957 TPX2 Homo sapiens Q9ULW0 32814053
Intra
DLST P36957 LGALS1 Homo sapiens P09382 32814053
Intra
DLST P36957 LGALS1 Homo sapiens P09382 32814053
Intra
DLST P36957 LGALS1 Homo sapiens P09382 32814053
Intra
DLST P36957 HUWE1 Homo sapiens Q7Z6Z7-2 32814053
Intra
DLST P36957 HUWE1 Homo sapiens Q7Z6Z7-2 32814053
Intra
DLST P36957 HUWE1 Homo sapiens Q7Z6Z7-2 32814053
Intra
DLST P36957 SP6 Homo sapiens Q3SY56 32814053
Intra
DLST P36957 SP6 Homo sapiens Q3SY56 32814053
Intra
DLST P36957 SP6 Homo sapiens Q3SY56 32814053
Intra
DLST P36957 EPCAM Homo sapiens P16422 32814053
Intra
DLST P36957 EPCAM Homo sapiens P16422 32814053
Intra
DLST P36957 EPCAM Homo sapiens P16422 32814053
Intra
DLST P36957 NEK6 Homo sapiens Q9HC98-4 32814053
Intra
DLST P36957 NEK6 Homo sapiens Q9HC98-4 32814053
Intra
DLST P36957 NEK6 Homo sapiens Q9HC98-4 32814053
Intra
DLST P36957 LGALS8 Homo sapiens O00214-2 32814053
Intra
DLST P36957 LGALS8 Homo sapiens O00214-2 32814053
Intra
DLST P36957 LGALS8 Homo sapiens O00214-2 32814053
Intra
DLST P36957 NFATC2IP Homo sapiens Q8NCF5-2 32814053
Intra
DLST P36957 NFATC2IP Homo sapiens Q8NCF5-2 32814053
Intra
DLST P36957 NFATC2IP Homo sapiens Q8NCF5-2 32814053
Intra
DLST P36957 TRNAU1AP Homo sapiens Q9NX07 32814053
Intra
DLST P36957 TRNAU1AP Homo sapiens Q9NX07 32814053
Intra
DLST P36957 TRNAU1AP Homo sapiens Q9NX07 32814053
Intra
DLST P36957 HSD3B1 Homo sapiens P14060 32814053
Intra
DLST P36957 HSD3B1 Homo sapiens P14060 32814053
Intra
DLST P36957 HSD3B1 Homo sapiens P14060 32814053
Intra
DLST P36957 FAHD2A Homo sapiens Q96GK7 32814053
Intra
DLST P36957 FAHD2A Homo sapiens Q96GK7 32814053
Intra
DLST P36957 FAHD2A Homo sapiens Q96GK7 32814053
Intra
DLST P36957 CRELD2 Homo sapiens Q6UXH1-2 32814053
Intra
DLST P36957 CRELD2 Homo sapiens Q6UXH1-2 32814053
Intra
DLST P36957 CRELD2 Homo sapiens Q6UXH1-2 32814053
Intra
DLST P36957 q9bq29_human Homo sapiens Q9BQ29 32814053
Intra
DLST P36957 q9bq29_human Homo sapiens Q9BQ29 32814053
Intra
DLST P36957 q9bq29_human Homo sapiens Q9BQ29 32814053
Intra
DLST P36957 USP12 Homo sapiens O75317 32814053
Intra
DLST P36957 USP12 Homo sapiens O75317 32814053
Intra
DLST P36957 USP12 Homo sapiens O75317 32814053
Intra
DLST P36957 THBS3 Homo sapiens P49746 32814053
Intra
DLST P36957 THBS3 Homo sapiens P49746 32814053
Intra
DLST P36957 THBS3 Homo sapiens P49746 32814053
Intra
DLST P36957 POC1A Homo sapiens Q8NBT0 32814053
Intra
DLST P36957 POC1A Homo sapiens Q8NBT0 32814053
Intra
DLST P36957 POC1A Homo sapiens Q8NBT0 32814053
Intra
DLST P36957 ISY1 Homo sapiens Q9ULR0 32814053
Intra
DLST P36957 ISY1 Homo sapiens Q9ULR0 32814053
Intra
DLST P36957 ISY1 Homo sapiens Q9ULR0 32814053
Intra
DLST P36957 ZHX1-C8orf76 Homo sapiens Q96EF9 32814053
Intra
DLST P36957 ZHX1-C8orf76 Homo sapiens Q96EF9 32814053
Intra
DLST P36957 ZHX1-C8orf76 Homo sapiens Q96EF9 32814053
Intra
DLST P36957 TMX3 Homo sapiens Q96JJ7-2 32814053
Intra
DLST P36957 TMX3 Homo sapiens Q96JJ7-2 32814053
Intra
DLST P36957 TMX3 Homo sapiens Q96JJ7-2 32814053
Intra
DLST P36957 NXPE1 Homo sapiens Q8N323 32814053
Intra
DLST P36957 NXPE1 Homo sapiens Q8N323 32814053
Intra
DLST P36957 NXPE1 Homo sapiens Q8N323 32814053
Intra
DLST P36957 MGC39372 Homo sapiens Q8TB02 32814053
Intra
DLST P36957 MGC39372 Homo sapiens Q8TB02 32814053
Intra
DLST P36957 MGC39372 Homo sapiens Q8TB02 32814053
Intra
DLST P36957 PRAM1 Homo sapiens Q96QH2 32814053
Intra
DLST P36957 PRAM1 Homo sapiens Q96QH2 32814053
Intra
DLST P36957 PRAM1 Homo sapiens Q96QH2 32814053
Intra
DLST P36957 PYGO1 Homo sapiens Q9Y3Y4 32814053
Intra
DLST P36957 PYGO1 Homo sapiens Q9Y3Y4 32814053
Intra
DLST P36957 PYGO1 Homo sapiens Q9Y3Y4 32814053
Intra
DLST P36957 MYNN Homo sapiens Q9NPC7 32814053
Intra
DLST P36957 MYNN Homo sapiens Q9NPC7 32814053
Intra
DLST P36957 MYNN Homo sapiens Q9NPC7 32814053
Intra
DLST P36957 NAP1L1 Homo sapiens P55209 29128334
Intra
DLST P36957 YWHAE Homo sapiens P62258 29128334
Intra
DLST P36957 YWHAE Homo sapiens P62258 29128334
Intra
DLST P36957 PSMD2 Homo sapiens Q13200 32814053
Intra
DLST P36957 PSMD2 Homo sapiens Q13200 32814053
Intra
DLST P36957 PSMD2 Homo sapiens Q13200 32814053
Intra
DLST P36957 RAP1B Homo sapiens P61224 32814053
Intra
DLST P36957 RAP1B Homo sapiens P61224 32814053
Intra
DLST P36957 RAP1B Homo sapiens P61224 32814053
Intra
DLST P36957 RAB3C Homo sapiens Q96E17 32814053
Intra
DLST P36957 RAB3C Homo sapiens Q96E17 32814053
Intra
DLST P36957 RAB3C Homo sapiens Q96E17 32814053
Intra
DLST P36957 CDK1 Homo sapiens P06493 29128334
Intra
DLST P36957 CDK1 Homo sapiens P06493 29128334
Intra
DLST P36957 HTT Homo sapiens P42858 32814053
Intra
DLST P36957 HTT Homo sapiens P42858 32814053
Intra
DLST P36957 HTT Homo sapiens P42858 32814053
Intra
DLST P36957 PIAS4 Homo sapiens Q8N2W9 32814053
Intra
DLST P36957 PIAS4 Homo sapiens Q8N2W9 32814053
Intra
DLST P36957 PIAS4 Homo sapiens Q8N2W9 32814053
Intra
DLST P36957 MAGEA2 Homo sapiens P43356 32814053
Intra
DLST P36957 MAGEA2 Homo sapiens P43356 32814053
Intra
DLST P36957 MAGEA2 Homo sapiens P43356 32814053
Intra
DLST P36957 NLRP3 Homo sapiens Q96P20 32814053
Intra
DLST P36957 NLRP3 Homo sapiens Q96P20 32814053
Intra
DLST P36957 NLRP3 Homo sapiens Q96P20 32814053
Intra
DLST P36957 SPRED2 Homo sapiens Q7Z698 32814053
Intra
DLST P36957 SPRED2 Homo sapiens Q7Z698 32814053
Intra
DLST P36957 SPRED2 Homo sapiens Q7Z698 32814053
Intra
DLST P36957 PSAT1 Homo sapiens Q9Y617 32814053
Intra
DLST P36957 PSAT1 Homo sapiens Q9Y617 32814053
Intra
DLST P36957 PSAT1 Homo sapiens Q9Y617 32814053
Intra
DLST P36957 RBM5 Homo sapiens P52756 32814053
Intra
DLST P36957 RBM5 Homo sapiens P52756 32814053
Intra
DLST P36957 RBM5 Homo sapiens P52756 32814053
Intra
DLST P36957 IDH1 Homo sapiens O75874 32814053
Intra
DLST P36957 IDH1 Homo sapiens O75874 32814053
Intra
DLST P36957 IDH1 Homo sapiens O75874 32814053
Intra
DLST P36957 RAB31 Homo sapiens Q13636 32814053
Intra
DLST P36957 RAB31 Homo sapiens Q13636 32814053
Intra
DLST P36957 RAB31 Homo sapiens Q13636 32814053
Intra
DLST P36957 RBM17 Homo sapiens Q96I25 32814053
Intra
DLST P36957 RBM17 Homo sapiens Q96I25 32814053
Intra
DLST P36957 RBM17 Homo sapiens Q96I25 32814053
Intra
DLST P36957 THAP7 Homo sapiens Q9BT49 32814053
Intra
DLST P36957 THAP7 Homo sapiens Q9BT49 32814053
Intra
DLST P36957 THAP7 Homo sapiens Q9BT49 32814053
Intra
DLST P36957 TDO2 Homo sapiens P48775 32814053
Intra
DLST P36957 TDO2 Homo sapiens P48775 32814053
Intra
DLST P36957 TDO2 Homo sapiens P48775 32814053
Intra
DLST P36957 PSMC4 Homo sapiens P43686 29128334
Intra
DLST P36957 PSMC4 Homo sapiens P43686 32814053
Intra
DLST P36957 PSMC4 Homo sapiens P43686 32814053
Intra
DLST P36957 PSMC4 Homo sapiens P43686 32814053
Intra
DLST P36957 C1orf216 Homo sapiens Q8TAB5 32814053
Intra
DLST P36957 C1orf216 Homo sapiens Q8TAB5 32814053
Intra
DLST P36957 C1orf216 Homo sapiens Q8TAB5 32814053
Intra
DLST P36957 GJA5 Homo sapiens P36382 32814053
Intra
DLST P36957 GJA5 Homo sapiens P36382 32814053
Intra
DLST P36957 GJA5 Homo sapiens P36382 32814053
Intra
DLST P36957 MMAB Homo sapiens Q96EY8 32814053
Intra
DLST P36957 MMAB Homo sapiens Q96EY8 32814053
Intra
DLST P36957 MMAB Homo sapiens Q96EY8 32814053
Intra
DLST P36957 MYBPHL Homo sapiens A2RUH7 32814053
Intra
DLST P36957 MYBPHL Homo sapiens A2RUH7 32814053
Intra
DLST P36957 MYBPHL Homo sapiens A2RUH7 32814053
Intra
DLST P36957 FUT2 Homo sapiens Q10981 32814053
Intra
DLST P36957 FUT2 Homo sapiens Q10981 32814053
Intra
DLST P36957 FUT2 Homo sapiens Q10981 32814053
Intra
DLST P36957 TPGS2 Homo sapiens Q68CL5-3 32814053
Intra
DLST P36957 TPGS2 Homo sapiens Q68CL5-3 32814053
Intra
DLST P36957 TPGS2 Homo sapiens Q68CL5-3 32814053
Intra
DLST P36957 RASSF2 Homo sapiens P50749 32814053
Intra
DLST P36957 RASSF2 Homo sapiens P50749 32814053
Intra
DLST P36957 RASSF2 Homo sapiens P50749 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DLST Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P75709 DLST Protein, Human (sf9, His) P36957 (D68-L453) ≥ 90%, as determined by reducing SDS-PAGE.

DLST Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81071 DLST Antibody WB, ELISA, IHC-P, IHC-F, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Paragangliomas 7
  • PGL7

Hereditary Paraganglioma-Pheochromocytoma Syndromes
  • Hereditary Pheochromocytoma-Paraganglioma

  • Hereditary Paraganglioma-Pheochromocytoma

  • Familial Pheochromocytoma-Paraganglioma

  • Paragangliomas 2

  • Paragangliomas 3

  • Paragangliomas 4

  • Sdhx-Related Paraganglioma-Pheochromocytoma

  • Familial Paraganglioma Syndrome

  • Familial Paraganglioma-Pheochromocytoma Syndromes

  • Fpgl

  • Fpgl/Pheo

  • Paragangliomas 1

  • Paraganglioma

Maple Syrup Urine Disease
  • MSUD

  • Bckd Deficiency

  • Branched-Chain Ketoaciduria

  • Branched-Chain Alpha-Keto Acid Dehydrogenase Deficiency

  • Keto Acid Decarboxylase Deficiency

  • Maple Syrup Urine Disease, Type Ii

  • Branched Chain Ketoaciduria

  • Classic Maple Syrup Urine Disease

  • Intermittent Maple Syrup Urine Disease

  • Maple Syrup Urine Disease, Type Ia

  • Ketoacidaemia

  • Bckdh Deficiency

  • Branched-Chain 2-Ketoacid Dehydrogenase Deficiency

  • Thiamine-Responsive Maple Syrup Urine Disease

  • Intermediate Maple Syrup Urine Disease

  • Maple Syrup Urine Disease Type 1a

  • Maple Syrup Urine Disease Type 1b

  • Maple Syrup Urine Disease Type 2

  • Maple Syrup Urine Disease, Type Ib

  • Dihydrolipoamide Dehydrogenase Deficiency

  • Branched-Chain Ketoacid Dehydrogenase Deficiency

  • Maple Syrup Disease

  • Ketoacidemia

  • Classic Bckd Deficiency

  • Classic Msud

  • Classic Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Classic Branched-Chain Ketoaciduria

  • Thiamine-Responsive Bckd Deficiency

  • Thiamine-Responsive Msud

  • Thiamine-Responsive Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Intermittent Bckd Deficiency

  • Intermittent Msud

  • Intermittent Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Maple Syrup Urine Disease 1a

  • MSUD1A

  • Maple Syrup Urine Disease Type Ia

  • Msud Type Ia

  • Maple Syrup Urine Disease 1b

  • MSUD1B

  • Maple Syrup Urine Disease Type Ib

  • Msud Type Ib

  • Maple Syrup Urine Disease 2

  • MSUD2

  • Maple Syrup Urine Disease Type Ii

  • Msud Type Ii

  • Nadh Cytochrome B5 Reductase Deficiency

  • Lactic Acidosis, Congenital Infantile, Due To Lad Deficiency

  • Ketonemia

  • Maple Syrup Urine Disease, Type 1b

  • Ketoacid Decarboxylase Deficiency

  • Oxoacid Decarboxylase Deficiency

  • Branched Chain Ketoacid Dehydrogenase Deficiency

  • Msud - [Maple-Syrup-Urine Disease]

  • Ketoaminoacidaemia

  • Bckd - [Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency]

  • Maple-Syrup-Urine Disorder

  • Maple-Syrup-Urine Syndrome

Hereditary Spastic Paraplegia 51
  • Autosomal Dominant Spastic Paraplegia 51

  • Cpsq4

  • Spastic Quadriplegic Cerebral Palsy 4

  • Spg51

  • Spastic Paraplegia 51, Autosomal Recessive

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris DLST VGNC VGNC:39988
Felis catus DLST VGNC VGNC:61522
Rattus norvegicus DLST RGD RGD:1359615
Mus musculus DLST MGD MGI:1926170
Bos taurus DLST VGNC VGNC:28097
Macaca mulatta DLST VGNC VGNC:71927
Others DLST NCBI