DLST - dihydrolipoamide S-succinyltransferase Gene
Also Known as DLTS; KGD2; PGL7
Species: Homo sapiens
About DLST
This gene has 16 transcripts (splice variants), 267 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 40.7), heart (RPKM 35.9) and 25 other tissues.
Summary
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
DLST Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001244883.2 | NP_001231812.1 | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 2 precursor |
| NM_001933.5 | NP_001924.2 | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables acyltransferase activity |
IMP
IMP: Inferred from mutant phenotype
|
30929736 | GOA |
| enables dihydrolipoyllysine-residue succinyltransferase activity |
IMP
IMP: Inferred from mutant phenotype
|
30929736 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16169070 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in tricarboxylic acid cycle |
IMP
IMP: Inferred from mutant phenotype
|
30929736 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
29211711 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
29211711 | GOA |
| part of oxoadipate dehydrogenase complex |
IDA
IDA: Inferred from direct assay
|
29191460 | GOA |
| part of oxoglutarate dehydrogenase complex |
IDA
IDA: Inferred from direct assay
|
29211711 | GOA |
DLST Protein Structure
Biotin_lipoyl: Biotin-requiring enzyme (72 - 143)
2-oxoacid_dh: 2-oxoacid dehydrogenases acyltransferase (catalytic domain) (222 - 451)
- 0
- 100
- 200
- 300
- 400
- 453 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
|
DLST Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
DLST | P36957 | KIAA1683 | Homo sapiens | A0JP07 | 32814053 | |
|
Intra
|
DLST | P36957 | KIAA1683 | Homo sapiens | A0JP07 | 32814053 | |
|
Intra
|
DLST | P36957 | KIAA1683 | Homo sapiens | A0JP07 | 32814053 | |
|
Intra
|
DLST | P36957 | CAMTA2 | Homo sapiens | O94983-5 | 32814053 | |
|
Intra
|
DLST | P36957 | CAMTA2 | Homo sapiens | O94983-5 | 32814053 | |
|
Intra
|
DLST | P36957 | CAMTA2 | Homo sapiens | O94983-5 | 32814053 | |
|
Intra
|
DLST | P36957 | EVA1B | Homo sapiens | Q9NVM1 | 32814053 | |
|
Intra
|
DLST | P36957 | EVA1B | Homo sapiens | Q9NVM1 | 32814053 | |
|
Intra
|
DLST | P36957 | EVA1B | Homo sapiens | Q9NVM1 | 32814053 | |
|
Intra
|
DLST | P36957 | TPX2 | Homo sapiens | Q9ULW0 | 32814053 | |
|
Intra
|
DLST | P36957 | TPX2 | Homo sapiens | Q9ULW0 | 32814053 | |
|
Intra
|
DLST | P36957 | TPX2 | Homo sapiens | Q9ULW0 | 32814053 | |
|
Intra
|
DLST | P36957 | LGALS1 | Homo sapiens | P09382 | 32814053 | |
|
Intra
|
DLST | P36957 | LGALS1 | Homo sapiens | P09382 | 32814053 | |
|
Intra
|
DLST | P36957 | LGALS1 | Homo sapiens | P09382 | 32814053 | |
|
Intra
|
DLST | P36957 | HUWE1 | Homo sapiens | Q7Z6Z7-2 | 32814053 | |
|
Intra
|
DLST | P36957 | HUWE1 | Homo sapiens | Q7Z6Z7-2 | 32814053 | |
|
Intra
|
DLST | P36957 | HUWE1 | Homo sapiens | Q7Z6Z7-2 | 32814053 | |
|
Intra
|
DLST | P36957 | SP6 | Homo sapiens | Q3SY56 | 32814053 | |
|
Intra
|
DLST | P36957 | SP6 | Homo sapiens | Q3SY56 | 32814053 | |
|
Intra
|
DLST | P36957 | SP6 | Homo sapiens | Q3SY56 | 32814053 | |
|
Intra
|
DLST | P36957 | EPCAM | Homo sapiens | P16422 | 32814053 | |
|
Intra
|
DLST | P36957 | EPCAM | Homo sapiens | P16422 | 32814053 | |
|
Intra
|
DLST | P36957 | EPCAM | Homo sapiens | P16422 | 32814053 | |
|
Intra
|
DLST | P36957 | NEK6 | Homo sapiens | Q9HC98-4 | 32814053 | |
|
Intra
|
DLST | P36957 | NEK6 | Homo sapiens | Q9HC98-4 | 32814053 | |
|
Intra
|
DLST | P36957 | NEK6 | Homo sapiens | Q9HC98-4 | 32814053 | |
|
Intra
|
DLST | P36957 | LGALS8 | Homo sapiens | O00214-2 | 32814053 | |
|
Intra
|
DLST | P36957 | LGALS8 | Homo sapiens | O00214-2 | 32814053 | |
|
Intra
|
DLST | P36957 | LGALS8 | Homo sapiens | O00214-2 | 32814053 | |
|
Intra
|
DLST | P36957 | NFATC2IP | Homo sapiens | Q8NCF5-2 | 32814053 | |
|
Intra
|
DLST | P36957 | NFATC2IP | Homo sapiens | Q8NCF5-2 | 32814053 | |
|
Intra
|
DLST | P36957 | NFATC2IP | Homo sapiens | Q8NCF5-2 | 32814053 | |
|
Intra
|
DLST | P36957 | TRNAU1AP | Homo sapiens | Q9NX07 | 32814053 | |
|
Intra
|
DLST | P36957 | TRNAU1AP | Homo sapiens | Q9NX07 | 32814053 | |
|
Intra
|
DLST | P36957 | TRNAU1AP | Homo sapiens | Q9NX07 | 32814053 | |
|
Intra
|
DLST | P36957 | HSD3B1 | Homo sapiens | P14060 | 32814053 | |
|
Intra
|
DLST | P36957 | HSD3B1 | Homo sapiens | P14060 | 32814053 | |
|
Intra
|
DLST | P36957 | HSD3B1 | Homo sapiens | P14060 | 32814053 | |
|
Intra
|
DLST | P36957 | FAHD2A | Homo sapiens | Q96GK7 | 32814053 | |
|
Intra
|
DLST | P36957 | FAHD2A | Homo sapiens | Q96GK7 | 32814053 | |
|
Intra
|
DLST | P36957 | FAHD2A | Homo sapiens | Q96GK7 | 32814053 | |
|
Intra
|
DLST | P36957 | CRELD2 | Homo sapiens | Q6UXH1-2 | 32814053 | |
|
Intra
|
DLST | P36957 | CRELD2 | Homo sapiens | Q6UXH1-2 | 32814053 | |
|
Intra
|
DLST | P36957 | CRELD2 | Homo sapiens | Q6UXH1-2 | 32814053 | |
|
Intra
|
DLST | P36957 | q9bq29_human | Homo sapiens | Q9BQ29 | 32814053 | |
|
Intra
|
DLST | P36957 | q9bq29_human | Homo sapiens | Q9BQ29 | 32814053 | |
|
Intra
|
DLST | P36957 | q9bq29_human | Homo sapiens | Q9BQ29 | 32814053 | |
|
Intra
|
DLST | P36957 | USP12 | Homo sapiens | O75317 | 32814053 | |
|
Intra
|
DLST | P36957 | USP12 | Homo sapiens | O75317 | 32814053 | |
|
Intra
|
DLST | P36957 | USP12 | Homo sapiens | O75317 | 32814053 | |
|
Intra
|
DLST | P36957 | THBS3 | Homo sapiens | P49746 | 32814053 | |
|
Intra
|
DLST | P36957 | THBS3 | Homo sapiens | P49746 | 32814053 | |
|
Intra
|
DLST | P36957 | THBS3 | Homo sapiens | P49746 | 32814053 | |
|
Intra
|
DLST | P36957 | POC1A | Homo sapiens | Q8NBT0 | 32814053 | |
|
Intra
|
DLST | P36957 | POC1A | Homo sapiens | Q8NBT0 | 32814053 | |
|
Intra
|
DLST | P36957 | POC1A | Homo sapiens | Q8NBT0 | 32814053 | |
|
Intra
|
DLST | P36957 | ISY1 | Homo sapiens | Q9ULR0 | 32814053 | |
|
Intra
|
DLST | P36957 | ISY1 | Homo sapiens | Q9ULR0 | 32814053 | |
|
Intra
|
DLST | P36957 | ISY1 | Homo sapiens | Q9ULR0 | 32814053 | |
|
Intra
|
DLST | P36957 | ZHX1-C8orf76 | Homo sapiens | Q96EF9 | 32814053 | |
|
Intra
|
DLST | P36957 | ZHX1-C8orf76 | Homo sapiens | Q96EF9 | 32814053 | |
|
Intra
|
DLST | P36957 | ZHX1-C8orf76 | Homo sapiens | Q96EF9 | 32814053 | |
|
Intra
|
DLST | P36957 | TMX3 | Homo sapiens | Q96JJ7-2 | 32814053 | |
|
Intra
|
DLST | P36957 | TMX3 | Homo sapiens | Q96JJ7-2 | 32814053 | |
|
Intra
|
DLST | P36957 | TMX3 | Homo sapiens | Q96JJ7-2 | 32814053 | |
|
Intra
|
DLST | P36957 | NXPE1 | Homo sapiens | Q8N323 | 32814053 | |
|
Intra
|
DLST | P36957 | NXPE1 | Homo sapiens | Q8N323 | 32814053 | |
|
Intra
|
DLST | P36957 | NXPE1 | Homo sapiens | Q8N323 | 32814053 | |
|
Intra
|
DLST | P36957 | MGC39372 | Homo sapiens | Q8TB02 | 32814053 | |
|
Intra
|
DLST | P36957 | MGC39372 | Homo sapiens | Q8TB02 | 32814053 | |
|
Intra
|
DLST | P36957 | MGC39372 | Homo sapiens | Q8TB02 | 32814053 | |
|
Intra
|
DLST | P36957 | PRAM1 | Homo sapiens | Q96QH2 | 32814053 | |
|
Intra
|
DLST | P36957 | PRAM1 | Homo sapiens | Q96QH2 | 32814053 | |
|
Intra
|
DLST | P36957 | PRAM1 | Homo sapiens | Q96QH2 | 32814053 | |
|
Intra
|
DLST | P36957 | PYGO1 | Homo sapiens | Q9Y3Y4 | 32814053 | |
|
Intra
|
DLST | P36957 | PYGO1 | Homo sapiens | Q9Y3Y4 | 32814053 | |
|
Intra
|
DLST | P36957 | PYGO1 | Homo sapiens | Q9Y3Y4 | 32814053 | |
|
Intra
|
DLST | P36957 | MYNN | Homo sapiens | Q9NPC7 | 32814053 | |
|
Intra
|
DLST | P36957 | MYNN | Homo sapiens | Q9NPC7 | 32814053 | |
|
Intra
|
DLST | P36957 | MYNN | Homo sapiens | Q9NPC7 | 32814053 | |
|
Intra
|
DLST | P36957 | NAP1L1 | Homo sapiens | P55209 | 29128334 | |
|
Intra
|
DLST | P36957 | YWHAE | Homo sapiens | P62258 | 29128334 | |
|
Intra
|
DLST | P36957 | YWHAE | Homo sapiens | P62258 | 29128334 | |
|
Intra
|
DLST | P36957 | PSMD2 | Homo sapiens | Q13200 | 32814053 | |
|
Intra
|
DLST | P36957 | PSMD2 | Homo sapiens | Q13200 | 32814053 | |
|
Intra
|
DLST | P36957 | PSMD2 | Homo sapiens | Q13200 | 32814053 | |
|
Intra
|
DLST | P36957 | RAP1B | Homo sapiens | P61224 | 32814053 | |
|
Intra
|
DLST | P36957 | RAP1B | Homo sapiens | P61224 | 32814053 | |
|
Intra
|
DLST | P36957 | RAP1B | Homo sapiens | P61224 | 32814053 | |
|
Intra
|
DLST | P36957 | RAB3C | Homo sapiens | Q96E17 | 32814053 | |
|
Intra
|
DLST | P36957 | RAB3C | Homo sapiens | Q96E17 | 32814053 | |
|
Intra
|
DLST | P36957 | RAB3C | Homo sapiens | Q96E17 | 32814053 | |
|
Intra
|
DLST | P36957 | CDK1 | Homo sapiens | P06493 | 29128334 | |
|
Intra
|
DLST | P36957 | CDK1 | Homo sapiens | P06493 | 29128334 | |
|
Intra
|
DLST | P36957 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
DLST | P36957 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
DLST | P36957 | HTT | Homo sapiens | P42858 | 32814053 | |
|
Intra
|
DLST | P36957 | PIAS4 | Homo sapiens | Q8N2W9 | 32814053 | |
|
Intra
|
DLST | P36957 | PIAS4 | Homo sapiens | Q8N2W9 | 32814053 | |
|
Intra
|
DLST | P36957 | PIAS4 | Homo sapiens | Q8N2W9 | 32814053 | |
|
Intra
|
DLST | P36957 | MAGEA2 | Homo sapiens | P43356 | 32814053 | |
|
Intra
|
DLST | P36957 | MAGEA2 | Homo sapiens | P43356 | 32814053 | |
|
Intra
|
DLST | P36957 | MAGEA2 | Homo sapiens | P43356 | 32814053 | |
|
Intra
|
DLST | P36957 | NLRP3 | Homo sapiens | Q96P20 | 32814053 | |
|
Intra
|
DLST | P36957 | NLRP3 | Homo sapiens | Q96P20 | 32814053 | |
|
Intra
|
DLST | P36957 | NLRP3 | Homo sapiens | Q96P20 | 32814053 | |
|
Intra
|
DLST | P36957 | SPRED2 | Homo sapiens | Q7Z698 | 32814053 | |
|
Intra
|
DLST | P36957 | SPRED2 | Homo sapiens | Q7Z698 | 32814053 | |
|
Intra
|
DLST | P36957 | SPRED2 | Homo sapiens | Q7Z698 | 32814053 | |
|
Intra
|
DLST | P36957 | PSAT1 | Homo sapiens | Q9Y617 | 32814053 | |
|
Intra
|
DLST | P36957 | PSAT1 | Homo sapiens | Q9Y617 | 32814053 | |
|
Intra
|
DLST | P36957 | PSAT1 | Homo sapiens | Q9Y617 | 32814053 | |
|
Intra
|
DLST | P36957 | RBM5 | Homo sapiens | P52756 | 32814053 | |
|
Intra
|
DLST | P36957 | RBM5 | Homo sapiens | P52756 | 32814053 | |
|
Intra
|
DLST | P36957 | RBM5 | Homo sapiens | P52756 | 32814053 | |
|
Intra
|
DLST | P36957 | IDH1 | Homo sapiens | O75874 | 32814053 | |
|
Intra
|
DLST | P36957 | IDH1 | Homo sapiens | O75874 | 32814053 | |
|
Intra
|
DLST | P36957 | IDH1 | Homo sapiens | O75874 | 32814053 | |
|
Intra
|
DLST | P36957 | RAB31 | Homo sapiens | Q13636 | 32814053 | |
|
Intra
|
DLST | P36957 | RAB31 | Homo sapiens | Q13636 | 32814053 | |
|
Intra
|
DLST | P36957 | RAB31 | Homo sapiens | Q13636 | 32814053 | |
|
Intra
|
DLST | P36957 | RBM17 | Homo sapiens | Q96I25 | 32814053 | |
|
Intra
|
DLST | P36957 | RBM17 | Homo sapiens | Q96I25 | 32814053 | |
|
Intra
|
DLST | P36957 | RBM17 | Homo sapiens | Q96I25 | 32814053 | |
|
Intra
|
DLST | P36957 | THAP7 | Homo sapiens | Q9BT49 | 32814053 | |
|
Intra
|
DLST | P36957 | THAP7 | Homo sapiens | Q9BT49 | 32814053 | |
|
Intra
|
DLST | P36957 | THAP7 | Homo sapiens | Q9BT49 | 32814053 | |
|
Intra
|
DLST | P36957 | TDO2 | Homo sapiens | P48775 | 32814053 | |
|
Intra
|
DLST | P36957 | TDO2 | Homo sapiens | P48775 | 32814053 | |
|
Intra
|
DLST | P36957 | TDO2 | Homo sapiens | P48775 | 32814053 | |
|
Intra
|
DLST | P36957 | PSMC4 | Homo sapiens | P43686 | 29128334 | |
|
Intra
|
DLST | P36957 | PSMC4 | Homo sapiens | P43686 | 32814053 | |
|
Intra
|
DLST | P36957 | PSMC4 | Homo sapiens | P43686 | 32814053 | |
|
Intra
|
DLST | P36957 | PSMC4 | Homo sapiens | P43686 | 32814053 | |
|
Intra
|
DLST | P36957 | C1orf216 | Homo sapiens | Q8TAB5 | 32814053 | |
|
Intra
|
DLST | P36957 | C1orf216 | Homo sapiens | Q8TAB5 | 32814053 | |
|
Intra
|
DLST | P36957 | C1orf216 | Homo sapiens | Q8TAB5 | 32814053 | |
|
Intra
|
DLST | P36957 | GJA5 | Homo sapiens | P36382 | 32814053 | |
|
Intra
|
DLST | P36957 | GJA5 | Homo sapiens | P36382 | 32814053 | |
|
Intra
|
DLST | P36957 | GJA5 | Homo sapiens | P36382 | 32814053 | |
|
Intra
|
DLST | P36957 | MMAB | Homo sapiens | Q96EY8 | 32814053 | |
|
Intra
|
DLST | P36957 | MMAB | Homo sapiens | Q96EY8 | 32814053 | |
|
Intra
|
DLST | P36957 | MMAB | Homo sapiens | Q96EY8 | 32814053 | |
|
Intra
|
DLST | P36957 | MYBPHL | Homo sapiens | A2RUH7 | 32814053 | |
|
Intra
|
DLST | P36957 | MYBPHL | Homo sapiens | A2RUH7 | 32814053 | |
|
Intra
|
DLST | P36957 | MYBPHL | Homo sapiens | A2RUH7 | 32814053 | |
|
Intra
|
DLST | P36957 | FUT2 | Homo sapiens | Q10981 | 32814053 | |
|
Intra
|
DLST | P36957 | FUT2 | Homo sapiens | Q10981 | 32814053 | |
|
Intra
|
DLST | P36957 | FUT2 | Homo sapiens | Q10981 | 32814053 | |
|
Intra
|
DLST | P36957 | TPGS2 | Homo sapiens | Q68CL5-3 | 32814053 | |
|
Intra
|
DLST | P36957 | TPGS2 | Homo sapiens | Q68CL5-3 | 32814053 | |
|
Intra
|
DLST | P36957 | TPGS2 | Homo sapiens | Q68CL5-3 | 32814053 | |
|
Intra
|
DLST | P36957 | RASSF2 | Homo sapiens | P50749 | 32814053 | |
|
Intra
|
DLST | P36957 | RASSF2 | Homo sapiens | P50749 | 32814053 | |
|
Intra
|
DLST | P36957 | RASSF2 | Homo sapiens | P50749 | 32814053 |
Recombinant DLST Proteins
| Art. -Nr. | Produktname | Accession | Reinheit |
|---|---|---|---|
| HY-P75709 | DLST Protein, Human (sf9, His) | P36957 (D68-L453) | ≥ 90%, as determined by reducing SDS-PAGE. |
DLST Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P81071 | DLST Antibody | WB, ELISA, IHC-P, IHC-F, ICC/IF | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Paragangliomas 7 |
|
|
| Hereditary Paraganglioma-Pheochromocytoma Syndromes |
|
|
| Maple Syrup Urine Disease |
|
|
| Hereditary Spastic Paraplegia 51 |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | DLST | VGNC | VGNC:39988 |
| Felis catus | DLST | VGNC | VGNC:61522 |
| Rattus norvegicus | DLST | RGD | RGD:1359615 |
| Mus musculus | DLST | MGD | MGI:1926170 |
| Bos taurus | DLST | VGNC | VGNC:28097 |
| Macaca mulatta | DLST | VGNC | VGNC:71927 |
| Others | DLST | NCBI |