SP6 - Sp6 transcription factor Gene

Also Known as AI1K; EPFN; KLF14; EPIPROFIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80320

About SP6

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,844,908-47,876,311 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues and 22 paralogues. Biased expression in placenta (RPKM 11.3), skin (RPKM 2.8) and 6 other tissues.

Summary

SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

SP6 Products (2)

mRNA Protein Name
NM_001258248.2 NP_001245177.1 transcription factor Sp6
NM_199262.3 NP_954871.1 transcription factor Sp6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP6 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (270 - 297)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (301 - 323)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

transcription factor Sp6

  • Kruppel-like factor 14

SP6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SP6 Q3SY56 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
SP6 Q3SY56 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
SP6 Q3SY56 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
SP6 Q3SY56 MALSU1 Homo sapiens Q96EH3
Validated Y2H
32296183
Intra
SP6 Q3SY56 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
SP6 Q3SY56 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
SP6 Q3SY56 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
SP6 Q3SY56 PRKACA Homo sapiens P17612
Validated Y2H
32814053
Intra
SP6 Q3SY56 PRKACA Homo sapiens P17612
Y2H Array
32814053
Intra
SP6 Q3SY56 PRKACA Homo sapiens P17612
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amelogenesis Imperfecta

  • Ai

  • Congenital Enamel Hypoplasia

  • Al - [Amelogenesis Imperfecta]
Hermansky-Pudlak Syndrome 6

  • HPS6

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 6

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Premenstrual Tension

  • Premenstrual Syndrome

  • Pmt - [Premenstrual Tension]

  • Premenstrual Tension Nos

  • Syndrome Of Menstruation
Brain Stem Infarction

  • Brain Stem Infarctions

  • Brainstem Infarction
Lesion Of Sciatic Nerve

  • Nerve Lesion Sciatic

  • Sciatic Neuropathy
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136893 SP-6-27 / Unkown
HY-P10092 SP6 Activator / Unkown
HY-RS13609 SP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-137635 Sp-6-Phe-cAMPS Activator / Unkown
HY-RS18223 Sp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20514 Usp53 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24700 Sp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SP6 VGNC VGNC:65588
Canis familiaris SP6 VGNC VGNC:46689
Macaca mulatta SP6 VGNC VGNC:77922
Bos taurus SP6 VGNC VGNC:35156
Mus musculus SP6 MGD MGI:1932575
Rattus norvegicus SP6 RGD RGD:1306768
Others SP6 NCBI