ERH - ERH mRNA splicing and mitosis factor Gene

Also Known as DROER

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2079

About ERH

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,380,128-69,398,299 (from NCBI)

This gene has 4 transcripts (splice variants) and 345 orthologues. Ubiquitous expression in colon (RPKM 61.2), kidney (RPKM 56.3) and 25 other tissues.

Summary

Enables methyl-CpG binding activity. Predicted to be involved in pyrimidine nucleoside metabolic process. Located in midbody and nucleus. Part of methylosome. [provided by Alliance of Genome Resources, Apr 2022]

ERH Products (1)

mRNA Protein Name
NM_004450.3 NP_004441.1 enhancer of rudimentary homolog

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
25284789 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
Cellular Component GO Annotation Evidence References Source
part of methylosome IDA
IDA: Inferred from direct assay
25284789 GOA
located in midbody IDA
IDA: Inferred from direct assay
15166316 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23145069 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERH Protein Structure

ER

ER: Enhancer of rudimentary (1 - 101)

  • 0
  • 104 a.a.
Protein Preferred Names Protein Names

enhancer of rudimentary homolog

ERH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ERH P84090 CENPH Homo sapiens Q9H3R5
Validated Y2H
32296183
Intra
ERH P84090 TASOR2 Homo sapiens Q5VWN6-2
Validated Y2H
25416956
Intra
ERH P84090 TASOR2 Homo sapiens Q5VWN6-2
Y2H Prey Pooling
25416956
Intra
ERH P84090 CHTOP Homo sapiens Q9Y3Y2-3
Validated Y2H
32296183
Intra
ERH P84090 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Prey Pooling
32296183
Intra
ERH P84090 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Array
32296183
Intra
ERH P84090 CHTOP Homo sapiens Q9Y3Y2
Validated Y2H
25416956
Intra
ERH P84090 CHTOP Homo sapiens Q9Y3Y2
Anti Tag CoIP
33961781
Intra
ERH P84090 SNRPD3 Homo sapiens P62318
Anti Bait CoIP
23236152
Intra
ERH P84090 SNRPD3 Homo sapiens P62318
Anti Tag CoIP
23236152
Intra
ERH P84090 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ERH P84090 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ERH P84090 ATP6V0C Homo sapiens P27449
Y2H Prey Pooling
32296183
Intra
ERH P84090 ATP6V0C Homo sapiens P27449
Y2H Array
32296183
Intra
ERH P84090 UPRT Homo sapiens Q96BW1
Validated Y2H
32296183
Intra
ERH P84090 TASOR2 Homo sapiens Q5VWN6
Anti Tag CoIP
33961781
Intra
ERH P84090 TASOR2 Homo sapiens Q5VWN6
Validated Y2H
32296183
Intra
ERH P84090 TASOR2 Homo sapiens Q5VWN6
Y2H Prey Pooling
32296183
Intra
ERH P84090 TASOR2 Homo sapiens Q5VWN6
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERH Proteins

Cat. No. Product Name Accession Purity
HY-P74169 ERH Protein, Human (N-His) P84090 (M1-K104) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Acute Maxillary Sinusitis

  • Acute Antritis
Primary Progressive Multiple Sclerosis

  • Ppms

  • Primary-Progressive Ms

  • Multiple Sclerosis, Primary Progressive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N20592 Pu-erh tea extract / Unkown
HY-N8589 (-)-Epiafzelechin-3-O-gallate / Unkown
HY-RS04495 ERH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18115 Erh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24589 Erh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ERH VGNC VGNC:72428
Felis catus ERH VGNC VGNC:61942
Mus musculus ERH MGD MGI:108089
Bos taurus ERH VGNC VGNC:28581
Canis familiaris ERH VGNC VGNC:40453
Rattus norvegicus ERH RGD RGD:1595409
Others ERH NCBI