ATG14 - autophagy related 14 Gene

Also Known as ATG14L; BARKOR; KIAA0831

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22863

About ATG14

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,366,391-55,411,830 (from NCBI)

This gene has 2 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in bone marrow (RPKM 13.8), testis (RPKM 7.6) and 25 other tissues.

Summary

Enables GTPase binding activity. Involved in several processes, including macroautophagy; regulation of phosphorylation; and response to mitochondrial depolarisation. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATG14 Products (1)

mRNA Protein Name
NM_014924.5 NP_055739.2 beclin 1-associated autophagy-related key regulator

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
25891078 GOA
enables phosphatidylinositol 3-kinase inhibitor activity IDA
IDA: Inferred from direct assay
21062745 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19050071 GOA
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
20713597 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
20713597 GOA
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
19270696 GOA
involved in autophagosome maturation IDA
IDA: Inferred from direct assay
10625637 GOA
involved in autophagosome membrane docking IDA
IDA: Inferred from direct assay
25686604 GOA
involved in cellular response to starvation IMP
IMP: Inferred from mutant phenotype
23878393 GOA
involved in early endosome to late endosome transport IDA
IDA: Inferred from direct assay
14617358 GOA
acts upstream of or within endosome to lysosome transport IGI
IGI: Inferred from genetic interaction
22797916 GOA
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
23878393 GOA
involved in mitophagy IMP
IMP: Inferred from mutant phenotype
23878393 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
21062745 GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process IDA
IDA: Inferred from direct assay
8999962 GOA
involved in post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23878393 GOA
involved in regulation of macroautophagy IDA
IDA: Inferred from direct assay
10625637 GOA
involved in regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
23878393 GOA
involved in response to mitochondrial depolarisation IMP
IMP: Inferred from mutant phenotype
23878393 GOA
Cellular Component GO Annotation Evidence References Source
located in autophagosome IDA
IDA: Inferred from direct assay
19270696 GOA
located in extrinsic component of omegasome membrane IDA
IDA: Inferred from direct assay
21518905 GOA
located in extrinsic component of phagophore assembly site membrane IDA
IDA: Inferred from direct assay
21518905 GOA
is active in phagophore assembly site IDA
IDA: Inferred from direct assay
20713597 GOA
located in phagophore assembly site membrane IDA
IDA: Inferred from direct assay
19270696 GOA
part of phosphatidylinositol 3-kinase complex, class III IPI
IPI: Inferred from physical interaction
25490155 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG14 Protein Structure

Atg14

Atg14: Vacuolar sorting 38 and autophagy-related subunit 14 (42 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
Protein Preferred Names Protein Names

beclin 1-associated autophagy-related key regulator

  • ATG14 autophagy related 14 homolog

ATG14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
35271311
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
23332761
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Pull Down
25490155
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
19050071
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
20562859
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
33961781
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
22493499
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
BioID
34524948
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
28514442
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
GMS
25490155
Intra
ATG14 Q6ZNE5 PIK3C3 Homo sapiens Q8NEB9
EM
25490155
Intra
ATG14 Q6ZNE5 MIS18A Homo sapiens Q9NYP9
Complementation
32296183
Intra
ATG14 Q6ZNE5 MIS18A Homo sapiens Q9NYP9
Y2H Array
32296183
Intra
ATG14 Q6ZNE5 MIS18A Homo sapiens Q9NYP9
Y2H Prey Pooling
32296183
Intra
ATG14 Q6ZNE5 MIS18A Homo sapiens Q9NYP9
Validated Y2H
32296183
Intra
ATG14 Q6ZNE5 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
32296183
Intra
ATG14 Q6ZNE5 FSD2 Homo sapiens A1L4K1
Y2H Array
32296183
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
33961781
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
BioID
34524948
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Pull Down
21062745
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Bait CoIP
23332761
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
28514442
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
22493499
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Pull Down
25490155
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
19050071
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
GMS
25490155
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
EM
25490155
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Y2H
22081109
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Y2H Prey Pooling
32296183
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Y2H Array
32296183
Intra
ATG14 Q6ZNE5 BECN1 Homo sapiens Q14457
Anti Tag CoIP
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATG14 Proteins

Cat. No. Product Name Accession Purity
HY-P71576 ATG14 Protein, Human (Myc, His) Q6ZNE5-1 (M1-R492) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Neurodegeneration With Brain Iron Accumulation

  • Nbia

  • Neurodegeneration With Brain Iron Accumulation Disorders

  • Neurodegeneration, With Brain Iron Accumulation
Liver Carcinoma In Situ

  • Carcinoma In Situ Of Liver And Biliary System

  • Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Vici Syndrome

  • Absent Corpus Callosum Cataract Immunodeficiency

  • VICIS

  • Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum

  • Dionisi Vici Sabetta Gambarara Syndrome

  • Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum

  • Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome

  • Dionisi-Vici-Sabetta-Gambarara Syndrome

  • Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145752 HaloPROTAC-E Inhibitor 98.76% Unkown
HY-156237 Beclin1-ATG14L interaction inhibitor 1 Inhibitor 99.88% Unkown
HY-RS01142 ATG14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18164 Atg14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24638 Atg14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATG14 VGNC VGNC:26252
Macaca mulatta ATG14 VGNC VGNC:107996
Canis familiaris ATG14 VGNC VGNC:38218
Rattus norvegicus ATG14 RGD RGD:1304610
Felis catus ATG14 VGNC VGNC:59997
Mus musculus ATG14 MGD MGI:1261775
Others ATG14 NCBI