ATG14 - autophagy related 14 Gene

Homo sapiens

Also known as ATG14L; BARKOR; KIAA0831

Gene ID: 22863 | Gene type: protein coding

About ATG14

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,366,391-55,411,830 (from NCBI)

This gene has 2 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in bone marrow (RPKM 13.8), testis (RPKM 7.6) and 25 other tissues.

Summary

Enables GTPase binding activity. Involved in several processes, including macroautophagy; regulation of phosphorylation; and response to mitochondrial depolarisation. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATG14 Products(1)

mRNA	Protein	Name
NM_014924.5	NP_055739.2	beclin 1-associated autophagy-related key regulator

ATG14 Protein Structure

Atg14

0
100
200
300
400
492 a.a.

Protein Preferred Names

Protein Names

beclin 1-associated autophagy-related key regulator

ATG14 autophagy related 14 homolog

Recombinant ATG14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71576	ATG14 Protein, Human (Myc, His)	Q6ZNE5 (M1-R492)	≥95%

Related Diseases

Diseases

Alias

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency	VICIS
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum	Dionisi Vici Sabetta Gambarara Syndrome
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum	Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome
Dionisi-Vici-Sabetta-Gambarara Syndrome	Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145752	HaloPROTAC-E	Inhibitor	99.62%	Unkown
HY-156237	Beclin1-ATG14L interaction inhibitor 1	Inhibitor	/	Unkown
HY-RS01142	ATG14 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ATG14	VGNC	VGNC:26252
Macaca mulatta	ATG14	VGNC	VGNC:107996
Canis familiaris	ATG14	VGNC	VGNC:38218
Rattus norvegicus	ATG14	RGD	RGD:1304610
Felis catus	ATG14	VGNC	VGNC:59997
Mus musculus	ATG14	MGD	MGI:1261775
Others	ATG14	NCBI

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