Klk1 - kallikrein 1 Gene

Also Known as Kal; KALA; Klk5; Klk7; Klk1l; Klna3; RGK-7; Klk1c7; RSKG-7; RATKALA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24523

Summary

Enables endopeptidase activity. Involved in several processes, including positive regulation of acute inflammatory response; positive regulation of apoptotic process; and response to nutrient. Located in acrosomal vesicle; apical part of cell; and nucleus. Biomarker of hypertension and pancreatitis. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to human KLK1 (Kallikrein 1). [provided by Alliance of Genome Resources, Apr 2022]

Klk1 Products (1)

mRNA Protein Name
NM_012593.2 NP_036725.2 kallikrein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
16231010 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of acute inflammatory response IMP
IMP: Inferred from mutant phenotype
17015177 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17015177 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17473535 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
12489811 RGD
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
12558526 RGD
located in apical part of cell IDA
IDA: Inferred from direct assay
12558526 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kallikrein 1

  • Kallikrein 1, renal/pancreas/salivary

  • esterase B

  • glandular kallikrein-7, submandibular/renal

  • kallikrein 1-like peptidase

  • kallikrein 1-related peptidase C7

  • kallikrein 5

  • kallikrein 7

  • kallikrein a3

  • kallikrein-related protein K1

  • proteinase A

  • renal k

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148949A Kallikrein 5-IN-2 TFA Inhibitor 99.53% Unkown
HY-182600 KLK6-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klk1 NCBI NCBI:3816