KLK1 - kallikrein 1 Gene

Also Known as hK1; KLKR; Klk6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3816

About KLK1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,819,146-50,823,787 (from NCBI)

This gene has 4 transcripts (splice variants), 47 orthologues, 12 paralogues and is associated with 1 phenotype. Biased expression in salivary gland (RPKM 569.2) and pancreas (RPKM 508.7).

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]

KLK1 Products (1)

mRNA Protein Name
NM_002257.4 NP_002248.1 kallikrein-1 preproprotein

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19232384 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK1 Protein Structure

Trypsin

Trypsin: Trypsin (25 - 254)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

kallikrein-1

  • glandular kallikrein 1

Recombinant KLK1 Proteins

Cat. No. Product Name Accession Purity
HY-P70144 Kallikrein-1 Protein, Human (HEK293, His, solution) NP_002248.1 (S23-S262) ≥ 95%, as determined by reducing SDS-PAGE. ≥ 95%, as determined by HPLC.
HY-P73262 Kallikrein-1 Protein, Human (HEK293, His) P06870 (S23-S262) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Kallikrein, Decreased Urinary Activity Of
Vascular Dementia

  • Dementia, Vascular

  • Multi Infarct Dementia

  • Multifocal Dementia

  • Dementia Vascular

  • Vascular Dementia, Susceptibility To

  • Dementia, Multi-Infarct

  • Multi-Infarct Dementia
Netherton Syndrome

  • NETH

  • Ns

  • Netherton Disease

  • Comel-Netherton Syndrome

  • Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

  • Bamboo Hair Syndrome

  • Ichthyosis Linearis Circumflexa

  • Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

  • Ilc

  • Nts

  • N Syndrome
Postpoliomyelitis Syndrome

  • Postpolio Syndrome

  • Post-Polio Syndrome

  • Post Polio Syndrome

  • Polio Late Effects

  • Post-Polio Muscular Atrophy

  • Post-Polio Sequelae

  • Post-Poliomyelitic Syndrome

  • Postpolio Sequelae

  • Postpoliomyelitic Syndrome

  • Postpoliomyelitis Sequelae
Hereditary Angioedema

  • Hereditary Angioneurotic Edema

  • Hereditary Angioedema Type 1

  • Hane

  • Angioedema, Hereditary

  • Hae

  • Angioedemas, Hereditary

  • Deficiency Of C1 Esterase Inhibitor

  • C1 Esterase Inhibitor Deficiency

  • C1 Inhibitor Deficiency

  • Familial Angioneurotic Edema

  • Hereditary Bradykinine-Induced Angioedema

  • Hereditary Non Histamine-Induced Angioedema

  • Hae 1

  • Hae-I

  • Hereditary Angioneurotic Edema Type 1

  • Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

  • Hereditary Angioedema Types I And Ii

  • Hereditary Angioneurotic Oedema

  • Familial Angioedema

  • Hae - [Hereditary Angioneurotic Oedema]

  • Bannister Disease, Hereditary

  • Quincke Disease Or Oedema

  • Hereditary Quincke Oedema
Colon Adenocarcinoma

  • Adenocarcinoma Of Colon

  • Adenocarcinoma Of The Colon

  • Colonic Adenocarcinoma
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148949A Kallikrein 5-IN-2 TFA Inhibitor 99.53% Unkown
HY-182600 KLK6-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KLK1 VGNC VGNC:74189
Rattus norvegicus KLK1 RGD RGD:2969
Mus musculus KLK1 MGD MGI:102850
Bos taurus KLK1 VGNC VGNC:57049
Others KLK1 NCBI